Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors: International Review of Neurobiology, cartea 95
Erkki Nissinenen Limba Engleză Hardback – 13 dec 2010
- Up-to-date summary of biochemistry and pharmacology of COMT and its inhibitors
- Preclinical models in COMT inhibitor devlopment
- Transgenic COMT mice – latest information summarized
- Chemistry of COMT inhibitors and their design with molecular modelling
- COMT gene and its regulation and relation to dopamine related diseases
- Role of cofactor SAM regulation in relation to homocysteine
- Nonclinical and clinical safety of COMT inhibitors summarized
- Future prospects of COMT inhibitors in Parkinson’s disease
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Specificații
ISBN-13: 9780123813268
ISBN-10: 0123813263
Pagini: 336
Dimensiuni: 152 x 229 x 19 mm
Greutate: 0.62 kg
Ediția:New.
Editura: ELSEVIER SCIENCE
Seria International Review of Neurobiology
ISBN-10: 0123813263
Pagini: 336
Dimensiuni: 152 x 229 x 19 mm
Greutate: 0.62 kg
Ediția:New.
Editura: ELSEVIER SCIENCE
Seria International Review of Neurobiology
Public țintă
Neuroscientists, neurologists, psychologistsCuprins
- Introductory remarks: Catechol-O-methyltransferase inhibition: an innovative approach to enhance L-dopa therapy in Parkinson’s disease with dual enzyme inhibition
Erkki Nissinen
- The catechol-O-methyltransferase gene, its regulation and polymorphisms
Elizabeth M. Tunbridge
- Distribution and functions of catechol-O-methyltransferase proteins: do recent findings change the picture?
Timo T. Myöhänen & Pekka T. Männistö
- Catechol-O-methyltransferase enzyme: Cofactor S-adenosyl-L-methionine and related mechanisms
Thomas Müller
- Biochemistry and pharmacology of catechol-O-methyltrasferase inhibitors
Erkki Nissinen and Pekka T. Männistö
- The Chemistry of Catechol-O-methyltransferase Inhibitors
David A. Learmonth, László E. Kiss and Patrício Soares-da-Silva
- Toxicology and safety of COMT inhibitors
Kristiina Haasio
- Catechol-O-methyltransferase inhibitors in preclinical models as adjuncts of the L-dopa treatment
Concepció Marin, J.A. Obeso
- Problems with the present inhibitors and a relevance of new and improved COMT inhibitors in Parkinson’s disease
Seppo Kaakkola
- Catechol-O-methyltransferase and pain