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Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors de Erkki Nissinen

Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors: International Review of Neurobiology, cartea 95

Erkki Nissinen
en Limba Engleză Hardback – 13 dec 2010
Volume 95 of International Review of Neurobiology focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson’s disease. Chapters cover COMT gene and proteins, L-dopa treatment in Parkinson’s disease, the latest research on COMT inhibitors and their clinical applications, as well as future prospects for their use.

  • Up-to-date summary of biochemistry and pharmacology of COMT and its inhibitors
  • Preclinical models in COMT inhibitor devlopment
  • Transgenic COMT mice – latest information summarized
  • Chemistry of COMT inhibitors and their design with molecular modelling
  • COMT gene and its regulation and relation to dopamine related diseases
  • Role of cofactor SAM regulation in relation to homocysteine
  • Nonclinical and clinical safety of COMT inhibitors summarized
  • Future prospects of COMT inhibitors in Parkinson’s disease
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Specificații

ISBN-13: 9780123813268
ISBN-10: 0123813263
Pagini: 336
Dimensiuni: 152 x 229 x 19 mm
Greutate: 0.62 kg
Ediția:New.
Editura: ELSEVIER SCIENCE
Seria International Review of Neurobiology

Public țintă

Neuroscientists, neurologists, psychologists

Cuprins

  1. Introductory remarks: Catechol-O-methyltransferase inhibition: an innovative approach to enhance L-dopa therapy in Parkinson’s disease with dual enzyme inhibition Erkki Nissinen
  2. The catechol-O-methyltransferase gene, its regulation and polymorphisms Elizabeth M. Tunbridge
  3. Distribution and functions of catechol-O-methyltransferase proteins: do recent findings change the picture? Timo T. Myöhänen & Pekka T. Männistö
  4. Catechol-O-methyltransferase enzyme: Cofactor S-adenosyl-L-methionine and related mechanisms Thomas Müller
  5. Biochemistry and pharmacology of catechol-O-methyltrasferase inhibitors Erkki Nissinen and Pekka T. Männistö
  6. The Chemistry of Catechol-O-methyltransferase Inhibitors David A. Learmonth, László E. Kiss and Patrício Soares-da-Silva
  7. Toxicology and safety of COMT inhibitors Kristiina Haasio
  8. Catechol-O-methyltransferase inhibitors in preclinical models as adjuncts of the L-dopa treatment Concepció Marin, J.A. Obeso
  9. Problems with the present inhibitors and a relevance of new and improved COMT inhibitors in Parkinson’s disease Seppo Kaakkola
  10. Catechol-O-methyltransferase and pain
Oleg Kambur & Pekka T. Männistö