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Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating Neurodegenerative Diseases as Metabolic Diseases de Grazyna Soderbom

Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating Neurodegenerative Diseases as Metabolic Diseases: International Review of Neurobiology, cartea 155

Grazyna Soderbom, Russell Esterline, Jan Oscarsson, Mark P. Mattson
en Limba Engleză Hardback – 25 aug 2020
Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disease reviews how the different aspects of metabolic dysfunction and consequent pathology associated with neurodegenerative diseases, including Alzheimer’s and Parkinson’s, can be targeted by novel treatment approaches. Topics covered include Cellular Senescence in Aging and Age-Related Disorders: Implications for Neurodegenerative Diseases; Repurposing GLP1 agonists for Neurodegenerative Diseases; Ketotherapeutics for Neurodegenerative Diseases; Enhancing Mitophagy as a Therapeutic Approach for Neurodegenerative Diseases; Harnessing Neurogenesis in the Adult Brain – A Role in Type 2 Diabetes Mellitus and Alzheimer’s disease; and much more.

  • Summarizes the impact of the metabolic hypothesis on underlying mechanisms of neurodegenerative diseases
  • Presents novel, potential treatment strategies based on the metabolic hypothesis for neurodegenerative diseases
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Specificații

ISBN-13: 9780128231210
ISBN-10: 0128231211
Pagini: 322
Dimensiuni: 152 x 229 mm
Greutate: 0.59 kg
Editura: ELSEVIER SCIENCE
Seria International Review of Neurobiology

Public țintă

Postgraduates and researchers in the areas of Neurobiology, Neurodegeneration, Alzheimer’s, Parkinson’s, Metabolic Disorders, Bioenergetics, Repurposing of Metabolic Treatments, Novel Treatments for Neurodegenerative Disorders.

Cuprins

1. Dysregulation of metabolic flexibility: The impact of mTOR on autophagy in neurodegenerative diseases
Kenneth Maiese
2. Antidiabetic drugs for Alzheimer´s and Parkinson´s diseases: Repurposing insulin, metformin and thiazolidinediones
Susana Cardoso and Paula I. Moreira
3. Evidence for pathophysiological commonalities between metabolic and neurodegenerative diseases
Christian Hölscher
4. Repurposing GLP1 agonists for neurodegenerative diseases
Ioanna Markaki, Kristian Winther, Sergiu-Bogdan Catrina and Per Svenningsson
5. A role for Sodium Glucose coTransporter 2 inhibitors (SGLT2i) in the treatment of Alzheimer's disease?
Russell Esterline, Jan Oscarsson and Jeffrey Burns
6. Ketotherapeutics for neurodegenerative diseases
Nicholas G. Norwitz, Javier Gilbert Jaramillo, Kieran Clarke and Adrian Soto
7. Enhancing mitophagy as a therapeutic approach for neurodegenerative diseases
Yahyah Aman, Brent Ryan, Silje Bøen Torsetnes, Anne-Brita Knapskog, Leiv Otto Watne, William A. McEwan and Evandro Fei Fang
8. Cellular senescence in aging and age-related disorders: Implications for neurodegenerative diseases
Erin O. Wissler Gerdes, Yi Zhu, Bettina M. Weigand, Utkarsh Tripathi, Terence C. Burns, Tamar Tchkonia and James L. Kirkland
9. Harnessing neurogenesis in the adult brain—A role in type-2-diabetes mellitus and Alzheimer’s disease
Orly Lazarov, Richard D. Minshall and Marcelo G. Bonini
10. Hormesis: A therapeutic strategic approach in the treatment of neurodegenerative disease
Edward J. Calabrese, Mark P. Mattson, Gaurav Dhawan, Rachna Kapoor, Vittorio Calabrese and James Giordano