Basic Clinical Radiobiology
Editat de Michael C Joiner, Albert van der Kogelen Limba Engleză Paperback – 23 dec 2024
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Specificații
ISBN-13: 9781032243818
ISBN-10: 1032243813
Pagini: 354
Ilustrații: 390
Dimensiuni: 210 x 280 x 19 mm
Greutate: 0.96 kg
Ediția:6
Editura: CRC Press
Colecția CRC Press
ISBN-10: 1032243813
Pagini: 354
Ilustrații: 390
Dimensiuni: 210 x 280 x 19 mm
Greutate: 0.96 kg
Ediția:6
Editura: CRC Press
Colecția CRC Press
Public țintă
ProfessionalCuprins
Preface
About the editors
List of contributors
Glossary
1. Introduction: The significance of radiobiology and radiotherapy for cancer treatment. 2. Irradiation-induced damage and the DNA damage response. 3. Cell death after irradiation – how, when and why cells die. 4. Quantifying cell kill and cell survival. 5. Radiation dose-response relationships. 6. Linear energy transfer and relative biological effectiveness. 7. Physics of radiation therapy for the radiobiologist. 8. Tumour growth and response to radiation. 9. Fractionation: The Linear-Quadratic approach. 10. The linear-quadratic approach in clinical practice. 11. Modified fractionation. 12. Early effects in epithelial tissues, the role of stem cells and time factors. 13. The dose-rate effect. 14. Pathogenesis of late normal tissue effects. 15. Volume effects, regional responses, and risk models. 16. Biological modifiers of normal tissue effects. 17. The oxygen effect and therapeutic approaches to tumour hypoxia. 18. The tumour microenvironment and cellular hypoxia responses. 19. Combined radiotherapy and chemotherapy from the perspective of the Radiation Oncologist. 20. Molecular targeted agents for enhancing tumour response. 21. Biological individualisation of radiotherapy. 22. Molecular image guided radiotherapy. 23. Retreatment tolerance of normal tissues. 24. Cancer stem cells in radiotherapy. 25. Hadron therapy: The clinical aspects. 26. Radiation and the immune system. 27. Second cancers after radiotherapy.
Index
About the editors
List of contributors
Glossary
1. Introduction: The significance of radiobiology and radiotherapy for cancer treatment. 2. Irradiation-induced damage and the DNA damage response. 3. Cell death after irradiation – how, when and why cells die. 4. Quantifying cell kill and cell survival. 5. Radiation dose-response relationships. 6. Linear energy transfer and relative biological effectiveness. 7. Physics of radiation therapy for the radiobiologist. 8. Tumour growth and response to radiation. 9. Fractionation: The Linear-Quadratic approach. 10. The linear-quadratic approach in clinical practice. 11. Modified fractionation. 12. Early effects in epithelial tissues, the role of stem cells and time factors. 13. The dose-rate effect. 14. Pathogenesis of late normal tissue effects. 15. Volume effects, regional responses, and risk models. 16. Biological modifiers of normal tissue effects. 17. The oxygen effect and therapeutic approaches to tumour hypoxia. 18. The tumour microenvironment and cellular hypoxia responses. 19. Combined radiotherapy and chemotherapy from the perspective of the Radiation Oncologist. 20. Molecular targeted agents for enhancing tumour response. 21. Biological individualisation of radiotherapy. 22. Molecular image guided radiotherapy. 23. Retreatment tolerance of normal tissues. 24. Cancer stem cells in radiotherapy. 25. Hadron therapy: The clinical aspects. 26. Radiation and the immune system. 27. Second cancers after radiotherapy.
Index
Notă biografică
Michael C Joiner, PhD is a founding teacher and previous Course Director of the Basic Clinical Radiobiology Course at ESTRO, and Advisor and Teacher of Clinical Radiobiology at Wayne State University, Detroit, Michigan, USA.
Albert J van der Kogel, PhD is a founding teacher and previous Course Director of the Basic Clinical Radiobiology Course at ESTRO, and Advisor and Teacher of Clinical Radiobiology at the University of Wisconsin, Madison, Wisconsin, USA.
Albert J van der Kogel, PhD is a founding teacher and previous Course Director of the Basic Clinical Radiobiology Course at ESTRO, and Advisor and Teacher of Clinical Radiobiology at the University of Wisconsin, Madison, Wisconsin, USA.
Descriere
The sixth edition of this internationally successful text includes the many positive advances in radiation oncology that have occurred over the past decade, and which continue to keep radiation at the cutting edge of cancer therapy.