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Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma de Juan Pedro Martinez-Barbera

Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma

Editat de Juan Pedro Martinez-Barbera, Cynthia Lilian Andoniadou
en Limba Engleză Paperback – 21 iul 2018
This astute volume brings together the latest expert research on adamantinomatous craniopharyngiomas (ACPs). ACPs are histologically benign but clinically aggressive tumors exhibiting a high propensity for local invasion into the hypothalamus, optic and vascular structures. These tumors, as well as the current treatments, may result in pan-hypopituitarism, diabetes insipidus, morbid obesity followed by type II diabetes mellitus, blindness, as well as serious behavioral and psychosocial impairments. Exploring in detail advances in both the understanding of tumor biology as well as clinical advances in patient management are explored in detail, this book will also look towards potential new treatment approaches.


Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma is the first book compiling all current research on ACPs. Mouse and human studies have unequivocally demonstrated that mutations in CTNNB1 encoding -catenin underliethe etiology of the majority, if not all ACP tumors. Genetic studies in mice have shown that ACPs are tumors of the pituitary gland and not of the hypothalamus as previously thought, and are derived from Rathke’s pouch precursors. In addition, a role for tissue-specific adult pituitary stem cells has been revealed as causative of ACP. Together, these studies have provided novel insights into the molecular and cellular etiology as well as the pathogenesis of human ACP. Finally, this volume covers new treatment approaches that have been shown to be effective both in reducing ACP burden as well as reducing the morbidity associated with therapy.      




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Specificații

ISBN-13: 9783319847702
ISBN-10: 3319847708
Pagini: 220
Ilustrații: XII, 220 p. 47 illus., 32 illus. in color.
Dimensiuni: 155 x 235 mm
Greutate: 0.33 kg
Ediția:Softcover reprint of the original 1st ed. 2017
Editura: Springer International Publishing
Colecția Springer
Locul publicării:Cham, Switzerland

Cuprins

Pathogenesis of human ACP.- Transcriptomic and Genomic Analyses of Human Craniopharyngioma.- Genetically Modified Mouse Models of Adamantinomatous Craniopharyngioma.- Clinical Diagnosis of Human ACP.- Endocrine Deficits in Patients with Human Craniopharyngioma.- Obesity and metabolic disturbances in Adamantinomatous Craniopharyngioma Patients.- Radiology and Radiotherapy of Craniopharyngioma.- Surgical Treatment of Human ACP.- Intracystic Administration of Interferon-Alpha for Reduction of Cystic Tumour Burden.- Long-term Management and Clinical Trials in Adamantinomatous Craniopharyngioma

Notă biografică

Professor Juan Pedro Martínez-Barberá is a leading expert in pituitary development and associated congenital disorders. He is a researcher at the Birth Defects Research Centre, Developmental Biology and Cancer Programme of the UCL Great Ormond Street Institute of Child Health.
Dr. Cynthia Lilian Andoniadou is a researcher at the Department of Craniofacial Development and Stem Cell Biology of King’s College London focusing on the biology of normal and pathogenic pituitary stem cells.


Textul de pe ultima copertă

This astute volume brings together the latest expert research on adamantinomatous craniopharyngiomas (ACPs). ACPs are histologically benign but clinically aggressive tumors exhibiting a high propensity for local invasion into the hypothalamus, optic and vascular structures. These tumors, as well as the current treatments, may result in pan-hypopituitarism, diabetes insipidus, morbid obesity followed by type II diabetes mellitus, blindness, as well as serious behavioral and psychosocial impairments. Exploring in detail advances in both the understanding of tumor biology as well as clinical advances in patient management are explored in detail, this book will also look towards potential new treatment approaches.


Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma is the first book compiling all current research on ACPs. Mouse and human studies have unequivocally demonstrated that mutations in CTNNB1 encoding -catenin underliethe etiology of the majority, if not all ACP tumors. Genetic studies in mice have shown that ACPs are tumors of the pituitary gland and not of the hypothalamus as previously thought, and are derived from Rathke’s pouch precursors. In addition, a role for tissue-specific adult pituitary stem cells has been revealed as causative of ACP. Together, these studies have provided novel insights into the molecular and cellular etiology as well as the pathogenesis of human ACP. Finally, this volume covers new treatment approaches that have been shown to be effective both in reducing ACP burden as well as reducing the morbidity associated with therapy.      

Caracteristici

The first book to target current research on adamantinomatous craniopharyngiomas (ACPs) Topics covered range from pathogenesis to clinical diagnosis to long-term management Includes novel and effective treatment approaches Includes supplementary material: sn.pub/extras