The story of the one hundred years (1918-2018) of the Missionary Society of St. Columban is filled with adventure, stress, and danger, with the humdrum of daily life, with martyrs (twenty-seven of them thus far, including Columban Sister Joan Sawyer), with innumerable personal and society global connections and issues, with men who went from the familiarity of daily life and people they knew to lands and people unknown to bring the good news. The story is charged with humor and courage, along with faith, hope, and love. The people in this story lived within particular national histories and an evolving global Christianity. The history of the US region of the Missionary Society of St. Columban interacts with movements of Catholic and American history. These contexts influenced the ability of the Columbans to grow in the United States, to provide desperately needed resources for the missions, and to further Catholic engagement in the mission.