Between the Lines of Genetic Code: Genetic Interactions in Understanding Disease and Complex Phenotypes
Editat de Leonid Padyukoven Limba Engleză Hardback – 28 noi 2013
Recent multivariate studies show that gene-gene and gene-environment interactions can explain significant variances in inheritance that have previously been undetectable in univariate analysis. These links among genes and between genes and their environments during the development of diseases may serve as important hints for understanding pathogenic mechanisms and for developing new tools for prognosis, diagnosis, and treatment of various diseases.
- Systematically integrates methods of defining and detecting gene interactions to provide an overview of the field
- Critically analyzes current methods and tools to aid researchers in integrating gene interaction studies
- Includes examples of current biomedical applications and presents current research expected to shape clinical research in the near future
Preț: 826.34 lei
Preț vechi: 1131.97 lei
-27% Nou
Puncte Express: 1240
Preț estimativ în valută:
158.16€ • 164.40$ • 131.01£
158.16€ • 164.40$ • 131.01£
Carte tipărită la comandă
Livrare economică 04-18 februarie 25
Preluare comenzi: 021 569.72.76
Specificații
ISBN-13: 9780123970176
ISBN-10: 0123970172
Pagini: 232
Ilustrații: black & white tables, figures
Dimensiuni: 152 x 229 x 18 mm
Greutate: 0.5 kg
Editura: ELSEVIER SCIENCE
ISBN-10: 0123970172
Pagini: 232
Ilustrații: black & white tables, figures
Dimensiuni: 152 x 229 x 18 mm
Greutate: 0.5 kg
Editura: ELSEVIER SCIENCE
Public țintă
Research geneticists; molecular and cell biologists; biologists, bioinformaticians, and biostatisticians with interests in human diseaseCuprins
1. Introduction2. Terminology and definitions for interaction studies 3. Multidimensional reduction in study of interaction 4. Study design for interaction 5. High throughput interaction study 6. Conclusions for the section7. Interaction in study of human complex diseases: Rheumatoid arthritis8. Interaction in study of human complex diseases: Multiple sclerosis9. Interaction in study of human complex diseases: Myositis10. Interaction in study of human complex diseases: other11. Conclusions for the section12. Functional studies of detected interactions in rheumatoid arthritis13. Complex patterns of interaction, genetic vectors14. From detection to understanding: pathways and networks 15. Conclusions for the section16. Conclusions for the book
Recenzii
"Specialists in genetic epidemiology and human genetics, most at the Karolinski Institute in Stockholm, review the current status of the field and clarify the main definitions, recent findings, and future directions. They consider such topics as reducing dimensionality in the search for gene-gene interactions, high-throughput genetic interaction studies, gene-gene and gene-environment interaction in rheumatoid arthritis…" --ProtoView.com, February 2014
"This book presents methodologies and tools for the measurement and evaluation of gene-gene and gene-environment studies of human diseases such as rheumatoid arthritis, multiple sclerosis, myositis, and other complex disorders…This is an excellent book on genetic interactions. Students, researchers, molecular biologists, and geneticists will find it quite useful." Rating: 3 Stars --Doody.com, January 24, 2014
"This book presents methodologies and tools for the measurement and evaluation of gene-gene and gene-environment studies of human diseases such as rheumatoid arthritis, multiple sclerosis, myositis, and other complex disorders…This is an excellent book on genetic interactions. Students, researchers, molecular biologists, and geneticists will find it quite useful." Rating: 3 Stars --Doody.com, January 24, 2014