FEATURES
Bridges the gap between the traditional statistical methods and computational tools for small genetic and epigenetic data analysis and the modern advanced statistical methods for big data
Provides tools for high dimensional data reduction
Discusses searching algorithms for model and variable selection including randomization algorithms, Proximal methods and matrix subset selection
Provides real-world examples and case studies
Will have an accompanying website with R code
Provides a natural extension and companion volume to Big Data in Omic and Imaging: Association Analysis, but can be read independently.
Introduce causal inference theory to genomic, epigenomic and imaging data analysis
Develop novel statistics for genome-wide causation studies and epigenome-wide causation studies.
Bridge the gap between the traditional association analysis and modern causation analysis
Use combinatorial optimization methods and various causal models as a general framework for inferring multilevel omic and image causal networks
Present statistical methods and computational algorithms for searching causal paths from genetic variant to disease
Develop causal machine learning methods integrating causal inference and machine learning
Develop statistics for testing significant difference in directed edge, path, and graphs, and for assessing causal relationships between two networks

The book is designed for graduate students and researchers in genomics, bioinformatics, and data science. It represents the paradigm shift of genetic studies of complex diseases– from shallow to deep genomic analysis, from low-dimensional to high dimensional, multivariate to functional data analysis with next-generation sequencing (NGS) data, and from homogeneous populations to heterogeneous population and pedigree data analysis. Topics covered are: advanced matrix theory, convex optimization algorithms, generalized low rank models, functional data analysis techniques, deep learning principle and machine learning methods for modern association, interaction, pathway and network analysis of rare and common variants, biomarker identification, disease risk and drug response prediction.