This books brings readers a holistic understanding of blockchain adoption in healthcare by not only considering the technical fundamentals of use cases, but also the regulatory, informational and organizational challenges and solutions. The book also provides frameworks and toolkits to manage the entire life cycle of adoption, including analysing the environment and feasibility, application design from a user-centred perspective, and implementation strategies that would overcome organizational and informational barriers. Specific issues addressed include but are not limited to: How to analyse the value propositions in healthcare and which distributed actors should be engaged to fulfil these propositions?  What policies and practices need to be reviewed to ensure security and privacy of the information shared? How to design blockchain systems that seamlessly integrate with other stakeholder applications, while only the needed information is in the distributed architecture? How canblockchain implementation be managed from governance and risk mitigation perspectives, especially when multiple actors are involved? By reading this book, blockchain enthusiasts, health informatics professionals and healthcare executives will be better prepared to leverage the transformative potential of blockchain for healthcare.