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Breaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells: Breaking Tolerance to Anti-Cancer Cell-Mediated Immunotherapy, cartea 6

Editat de Sandro Matosevic
en Limba Engleză Hardback – 31 aug 2024
Breaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells presents chapters by leaders in translational natural killer cell research and bridges the gap between clinical need and basic science by presenting state-of-the-art knowledge on innate immunity and the challenges associated with translating it to practical adoptive immunotherapies. New approaches, such as the genetic engineering of NK cells and their combination with checkpoint blockade therapies are discussed among other potential interventions to improve natural killer cell functionality against targets. In addition, challenges, such as the difficulty in genetically modifying NK cells or a poor understanding of their effect on checkpoint inhibition are included.The book is a key reference and go-to resource for researchers and clinicians who want to understand the current limitations associated with bringing natural killer cell-based immunotherapies to the clinic.

  • Discusses translational aspects from leaders in the field to facilitate readers’ understanding of clinical challenges
  • Addresses important events that occur in patient tumor microenvironments as they pertain to NK cells and how they are, or can be, tackled to overcome immunosuppression of NK cells
  • Focuses on immunometabolism by discussing the metabolic reprogramming that NK cells undergo in solid tumors, including hypoxia, adenosine and other metabolites
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Specificații

ISBN-13: 9780128206270
ISBN-10: 0128206276
Pagini: 200
Dimensiuni: 191 x 235 mm
Editura: ELSEVIER SCIENCE
Seria Breaking Tolerance to Anti-Cancer Cell-Mediated Immunotherapy


Public țintă

Cancer researchers, medical scientists, clinicians, graduate students

Cuprins

1. Expanding the persistence of adoptively-transferred NK cells: Cytokine priming and epigenetic imprinting
2. Targeting purinergic signaling to improve natural killer cells immunotherapy of solid tumors
3. Genetic engineering of CD19-targeted chimeric antigen-receptor NK cells derived from cord blood as clinical treatment for immunotherapy of B cell lymphoma
4. New sources of functionally-mature NK cells: peripheral blood-derived induced pluripotent stem cells
5. The contribution of natural killer cells to immunotherapy with PD-1/PD-L1 checkpoint blockade
6. Molecular checkpoints controlling NK cell activation and anti-tumor immunity
7. Exploiting hypoxia’s role in driving functional responses by IL-15-primed NK cells to target solid tumors
8. Metabolic reprogramming and the role of mTOR in driving NK cell anti-tumor immunity
9. Allo-reactive NK cells in immunotherapy of lung cancer: a clinical perspective
10. Control of tumor metastasis by NK cells
11. Challenges and opportunities with NK cells in the clinical treatment of acute myeloid leukemia