One of the most seminal Captain America runs of all time reaches a climax that pulls Cap into the war on drugs - with life-shattering consequences! Captain America joins the war on drugs! When Cap targets the gang that's selling the new designer narcotic Ice, he receives an accidental overdose that combines with the Super-Soldier Serum in his blood. Left permanently enraged, a volatile shield-slinger finds himself in the middle of a street war between the Red Skull and the Kingpin. With deadly villains Crossbones and Bullseye on each side, Cap will need to rely on his friends. But the Ice-induced rage is alienating him from allies like Daredevil and the Black Widow - and even his girlfriend, Diamondback. Steve must get free of the powerful drug, but it will come at a cost. Will he be fit to celebrate his 50th anniversary - or to face the Serpent Society, the Watchdogs and... Iron Man?! Collecting: Captain America (1968) #372-386 and Annual #9-10