Deir al-Surian, the famous Monastery of the Syrians in Egypt, has long been known for its unique collection of Syriac, Coptic, Arabic, and Ethiopian manuscripts. This catalogue provides detailed descriptions of the 48 Syriac manuscripts (many of them composite) and the more than 180 fragments that are preserved in the Monastery today. Ranging in date from the 5th to the 18th century and with a majority of them being earlier than the 10th century, the manuscripts present us with major authors and works of the Syriac literary tradition. They include biblical texts (among them the earliest dated Gospel manuscript in any language), original Syriac compositions, and translations from Greek and (occasionally) Coptic. Several works were previously unattested. Connections with manuscripts from Deir al-Surian that are preserved in European collections (primarily the British Library) are indicated wherever relevant. Colophons and various kinds of notes by scribes, readers, owners, and occasional visitors also receive attention, thus allowing interesting glimpses into the history not only of individual manuscripts, but also of the Monastery and its library. Accompanying the catalogue is an album containing more than 300 pages of images.