Cellular Bioenergetics: Role of Coupled Creatine Kinases: Developments in Molecular and Cellular Biochemistry, cartea 13
Editat de Valdur A. Saks, Renée Ventura-Clapieren Limba Engleză Paperback – 20 oct 2012
For biochemists, biophysicists, physiologists, and medical research workers.
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Specificații
ISBN-13: 9781461361190
ISBN-10: 1461361192
Pagini: 356
Ilustrații: V, 346 p.
Dimensiuni: 210 x 279 x 19 mm
Greutate: 0.8 kg
Ediția:Softcover reprint of the original 1st ed. 1994
Editura: Springer Us
Colecția Springer
Seria Developments in Molecular and Cellular Biochemistry
Locul publicării:New York, NY, United States
ISBN-10: 1461361192
Pagini: 356
Ilustrații: V, 346 p.
Dimensiuni: 210 x 279 x 19 mm
Greutate: 0.8 kg
Ediția:Softcover reprint of the original 1st ed. 1994
Editura: Springer Us
Colecția Springer
Seria Developments in Molecular and Cellular Biochemistry
Locul publicării:New York, NY, United States
Public țintă
ResearchCuprins
Preface.- I — Muscle Energy Metabolism.- 1a. Introduction: history of the problem.- 1b. A brief summary of the history of the detection of creatine kinase isoenzymes.- 2. Metabolic regulation of in vivo myocardial contractile function: multiparameter analysis.- 3. Compartmentation of ATP synthesis and utilization in smooth muscle: roles of aerobic glycolysis and creatine kinase.- 4. Creatine metabolism and the consequences of creatine depletion in muscle.- II — Substrate and Creatine Kinase Isoenzyme Compartmentation.- 1. The importance of the outer mitochondrial compartment in regulation of energy metabolism.- 2. The influence of the cytosoliconcotic pressure on the permeability of the mitochondrial outer membrane for ADP: implications for the kinetic properties of mitochondrial creatine kinase and for ADP channelling into the intermembrane space.- 3. Influence of mitochondrial creatine kinase on the mitochondrial/extramitochondrial distribution of high energy phosphates in muscle tissue: evidence for a leak in the creatine shuttle.- 4. The structure of mitochondrial creatine kinase and its membrane binding properties.- 5. Myofibrillar creatine kinase and cardiac contraction.- 6. Interaction of creatine kinase and adenylate systems in muscle cells.- III — Creatine Kinases and Metabolic Integration.- 1. Metabolic compartmentation and substrate channelling in muscle cells. Role of coupled creatine kinases in in vivo regulation of cellular respiration — a synthesis.- 2. Creatine kinase in non-muscle tissues and cells.- 3. The creatine kinase system in smooth muscle.- IV — Molecular Biology of Creatine Kinases.- 1. Expression of the mitochondrial creatine kinase genes.- 2. Sequence homology and structure predictions of the creatine kinase isoenzymes.- 3.Approaching the multifaceted nature of energy metabolism: inactivation of the cytosolic creatine kinases via homologous recombination in mouse embryonic stem cells.- V — Development and Pathological Alterations of Creatine Kinases.- 1. Compartmentation of creatine kinases during perinatal development of mammalian heart.- 2. In situ study of myofibrils, mitochondria and bound creatine kinases in experimental cardiomyopathies.- 3. Thyroid hormones and the creatine kinase system in cardiac cells.- VI — Metabolic Regulation: Theoretical Basis.- 1. Control theory of metabolic channelling.- 2. Mathematical modeling of intracellular transport processes and the creatine kinase systems: a probability approach.