Telomerases – Chemistry, Biology, and Clinical Applications de N Lue

Telomerases – Chemistry, Biology, and Clinical Applications

N Lue

This book is a comprehensive and up-to-date review and evaluation of the contemporary status of telomerase research. Chapters in this volume cover the basic structure, mechanisms, and diversity of the essential and regulatory subunits of telomerase. Other topics include telomerase biogenesis, transcriptional and post-translational regulation, off-telomere functions of telomerase and the role of telomerase in cellular senescence, aging and cancer. Its relationship to retrotransposons, a class of mobile genetic elements that shares similarities with telomerase and serves as telomeres in selected organisms, are also reviewed.

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Preface vii Contributors ix 1 The Telomerase Complex: An Overview 1 Johanna Mancini and Chantal Autexier 2 Telomerase RNA: Structure, Function, and Molecular Mechanisms 23 Yehuda Tzfati and Julian J.-L. Chen 3 TERT Structure, Function, and Molecular Mechanisms 53 Emmanuel Skordalakes and Neal Lue 4 Telomerase Biogenesis: RNA Processing, Trafficking, and Protein Interactions 79 Tara Beattie and Pascal Chartrand 5 Transcriptional Regulation of Human Telomerase 105 Antonella Farsetti and Yu-Sheng Cong 6 Telomerase Regulation and Telomere-Length Homeostasis 135 Joachim Lingner and David Shore 7 Telomere Structure in Telomerase Regulation 157 Momchil D. Vodenicharov and Raymund J. Wellinger 8 Off-Telomere Functions of Telomerase 201 Kenkichi Masutomi and William C. Hahn 9 Murine Models of Dysfunctional Telomeres and Telomerase 213 Yie Liu and Lea Harrington 10 Cellular Senescence, Telomerase, and Cancer in Human Cells 243 Phillip G. Smiraldo, Jun Tang, Jerry W. Shay, and Woodring E. Wright 11 Telomerase, Retrotransposons, and Evolution 265 Irina R. Arkhipova

Notă biografică

NEAL F. LUE, MD, PhD, is Professor in the Department of Microbiology and Immunology at Weill Cornell Medical College. He received his BS from Johns Hopkins University and his MD and PhD from Stanford University. His laboratory studies the structures and mechanisms of the telomere and telomerase complexes in a variety of fungal model systems. CHANTAL AUTEXIER, PhD, is Professor in the Department of Anatomy and Cell Biology and the Department of Medicine at McGill University. She received her BSc from Concordia University and her PhD from McGill University. Her laboratory studies the mechanisms that regulate telomerase and telomere functions in mammalian cells, and evaluates the principles of anticancer strategies that target these mechanisms.