The political change and unrest that have swept through the Middle East and North Africa since early 2011 are likely to have profound consequences for the pursuit of long-standing U.S. policy goals in the region with regard to regional security, global energy supplies, U.S. military access, bilateral trade and investment, counter-proliferation, counter-terrorism, and the promotion of human rights. The profound changes in the region may alter the framework in which these goals are pursued and challenge the basic assumptions that have long guided U.S. policy. This book assesses some of the policy implications of recent and ongoing events in the region, with a focus on Egypt, Iran, Syria, Libya, Israel, Tunisia, and Bahrain.