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Chiral Ligands: Evolution of Ligand Libraries for Asymmetric Catalysis: New Directions in Organic & Biological Chemistry

Editat de Montserrat Diéguez
en Limba Engleză Paperback – 27 mai 2024
Many new drugs on the market are chiral compounds, that is, they can exist in two non-superimposable mirror-image forms. Asymmetric catalysis encompasses a large variety of processes for obtaining such compounds. The performance of the catalyst in those processes largely depends on the ligand that makes up the catalyst. This book describes the most relevant ligand libraries for some key processes, including an overview of the state of art and the key mechanistic aspects that favor a high catalytic performance.
Key Features:
  • The book presents historical content from the time of discovery for each family of ligands.
  • Provides a description of the synthetic route and the ligand library's application in various catalytic asymmetric reactions
  • Suitable as supplementary reading for courses targeting the design, synthesis and application of chiral catalysts, asymmetric catalysis and sustainable production
  • Edited by a distinguished scientist in the field, the book has a diverse audience including research groups in homogeneous catalysis, particularly asymmetric transformations
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Specificații

ISBN-13: 9780367761707
ISBN-10: 036776170X
Pagini: 338
Ilustrații: 724
Dimensiuni: 156 x 234 x 21 mm
Greutate: 0.45 kg
Ediția:1
Editura: CRC Press
Colecția CRC Press
Seria New Directions in Organic & Biological Chemistry

Locul publicării:Boca Raton, United States

Public țintă

Academic, Postgraduate, Professional, Professional Practice & Development, and Undergraduate Advanced

Cuprins

Contents
Preface......................................................................................................................vii
Editor.........................................................................................................................ix
List of Contributors....................................................................................................xi
Abbreviations and Acronyms................................................................................. xiii
Chapter 1 Chiral Bidentate Heterodonor P-Oxazoline Ligands ...........................1
Maria Biosca, Jordi Faiges, Montserrat Diéguez,
and Oscar Pàmies
Chapter 2 Chiral Bidentate Heterodonor P-N-Other-Ligands............................. 33
Pep Rojo, Marina Bellido, Xavier Verdaguer, and Antoni Riera
Chapter 3 Chiral Bidentate Heterodonor P,S/O Ligands..................................... 81
Jèssica Margalef and Miquel A. Pericàs
Chapter 4 Chiral Bidentate Heterodonor P-P’ ligands....................................... 109
Antonio Pizzano
Chapter 5 Chiral Tridentate-Based Ligands...................................................... 167
Uchchhal Bandyopadhyay, Basker Sundararaju, Rinaldo Poli,
and Eric Manoury
Chapter 6 Chiral N-Heterocyclic Carbene-Based Ligands................................ 195
Vincent César, Christophe Fliedel, and Agnès Labande
Chapter 7 Chiral Monophosphorus Ligands...................................................... 233
Wenjun Tang, Feng Wan, and He Yang
Chapter 8 Solvent-Oriented Ligand and Catalyst Design in Asymmetric
Catalysis – Principles and Limits ..................................................... 261
Armin Börner
Index....................................................................................................................... 315

Notă biografică

Montserrat Diéguez studied chemistry at the Rovira i Virgili University (URV)
in Tarragona (Spain), where she earned her Ph.D. in 1997, working in the group
of Prof. C. Claver. After completing a postdoctoral fellowship where she worked
with Prof. R.H. Crabtree at Yale University, in New Haven (USA), she returned to
Tarragona in 1999 and accepted a lectureship position at the URV, becoming part of
the permanent staff in 2002. In 2011 she was promoted to full Professor in Inorganic
Chemistry at the URV.
She has been involved in more than 60 research projects in the fields of organometallic
chemistry, steroselective synthesis, and asymmetric catalysis. She is the
author/co-author of more than 150 articles in SCI-indexed journals and book chapters,
and of several contributions to conferences. She received distinction from the
Generalitat de Catalunya for the promotion of University Research in 2004 and from
the URV in 2008. She has also been awarded the ICREA Academia Prize from
the Catalan Institution for Research and Advanced Studies 2009–14 and 2015–20,
for research excellence, facilitating research priority dedication. Her main research
interests are focused on the sustainable design, synthesis, and screening of highly
active and selective chiral catalysts for reactions of interest to the biological, pharmaceutical,
and organic nanotechnological industries. Her areas of interest include
organometallic chemistry, stereoselective synthesis, and asymmetric catalysis, using
combinatorial and biotechnological approaches.

Descriere

Many new drugs on the market are chiral compounds, that is, they can exist in two non-superimposable mirror-image forms. Asymmetric catalysis encompasses a large variety of processes for obtaining such compounds.