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Chirality in Drug Design and Development

Editat de Indra K. Reddy, Reza Mehvar
en Limba Engleză Hardback – 15 mar 2004
Covering every essential element in the development of chiral products, this reference provides a solid overview of the formulation, biopharmaceutical characteristics, and regulatory issues impacting the production of these pharmaceuticals. It supports researchers as they evaluate the pharmacodynamic, pharmacokinetic, and toxicological characteristics of specific enantiomers and chiral drug compounds and addresses in one convenient reference all the major challenges pertaining to drug chirality that have been neglected in the literature. Chirality in Drug Design and Development collects the latest studies from an interdisciplinary team of experts on chiral drug design.
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Specificații

ISBN-13: 9780824750626
ISBN-10: 0824750624
Pagini: 464
Ilustrații: 7 halftones
Dimensiuni: 152 x 229 x 239 mm
Greutate: 0.74 kg
Ediția:1
Editura: CRC Press
Colecția CRC Press

Public țintă

Professional

Cuprins

Foreword, Fakhreddin Jamali, Preface, Contributors, 1. Effects of Crystal Structure and Physical Properties on the Release of Chiral Drugs, 2. Use of Chiral Excipients in Formulations Containing Chiral Drugs, 3. Transport of Chiral Molecules Across the Skin, 4. Stereoselective Drug Delivery Through Prodrug Approach, 5. Stereoselectivity in Drug Action and Disposition: An Overview, 6. Stereospecific Pharmacokinetics and Pharmacodynamics: Selected Classes of Drugs, 7. Stereospecific Pharmacokinetics and Pharmacodynamics: Cardiovascular Drugs, 8. Chiral Inversion, 9. Bioequivalency Determination of Racemic Drug Formulations: Is Stereospecific Assay Essential?, 10. Regulatory Considerations in Drug Development of Stereoisomers, Index

Descriere

Covering every essential element in the development of chiral products, this book provides a solid overview of recent breakthroughs in formulation, biopharmaceutical characteristics, and regulatory issues impacting the production of these pharmaceuticals. Chirality in Drug Design and Development supports researchers as they evaluate the pharmacodynamic, pharmacokinetic, and toxicological characteristics of specific enantiomers and chiral drug compounds and addresses in one convenient reference all the major challenges pertaining to drug chirality that have been neglected in the literature. This reference collects the recent studies and advances from an interdisciplinary team of experts on chiral drug design.