The separation of Church from Synagogue was not a one-time act, but a long-lasting, multilayered, and diversified process. The attempt to explain this process, namely the process of parting of the ways between Judaism and Christianity in the years 30-313 AD, constitutes the main research subject of this publication. The aim of this study is the presentation of the dynamism of Christian-Jewish relations in the first three centuries of the existence of the Church, taking into account mainly historical and theological (but not the only) factors which influenced these relations and finally led to the creation of two separate religions. The two religions existing side by side were in many aspects connected with each other mostly because both originated from biblical Judaism.