In a world where monsters called Yoma prey on humans and live among them in disguise, humanity's only hope is a new breed of warrior known as Claymores. Half human, half monster, these silver-eyed slayers possess supernatural strength but are condemned to fight their savage impulses or lose their humanity completely.

Priscilla, whose monstrous savagery was reawakened in the previous battle, is bent on absorbing the power of those who fell in her wake and destroying the rebel Claymores. Raki and several former top warriors band together with defensive plan, but even their skills may be no match against Priscilla's poisoned wrath. Meanwhile, the terrifying Yoma-based creature coalescing outside of the holy city of Rabona may also seek to defeat Priscilla…but it may also be seeking the defeat of the rebel warriors!