A Claymore - a female warrior named for the sword she carries - travels from medieval village to village to destroy Yoma, monsters who disguise themselves as humans and who are almost impossible to kill. Claymores are half-humans, half-demons who willingly transformed themselves by mixing their blood with monster's blood. Claire, nicknamed silver-eyed killer, is such a powerful Claymore, she can slay a Yoma using only one hand. But she must constantly struggle to keep from becoming a monster herself.

Clare's first battle with the Yoma of Rabona has left her body drained and shattered. With no time to recover, she must face the creature again after it chooses Raki as its next victim. Luckily, Raki remembers that he is carrying Clare's trusted broadsword and manages to get it into her hands. But unlike Clare, the Yoma is fighting at full strength and thirsting for blood...