The integration of a broad array of interventions is described in this comprehensive, practical guide for those working with seriously mentally ill adults. It draws on the experience of clients who struggle with severe and disabling problems in a challenging urban environment. The contributors argue that psychological and practical issues are intertwined and therefore such interventions must be delivered concurrently. They also emphasize that understanding and using the resources of a client's culture is critical to the successful implementation of care, and that families and natural support systems are essential components of the care system.