Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials
Autor Tony K.L. Kiang, Kyle John Wilby, Mary H.H. Ensomen Limba Engleză Hardback – 26 noi 2014
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Specificații
ISBN-13: 9783319105260
ISBN-10: 3319105264
Pagini: 120
Ilustrații: VII, 146 p. 1 illus. in color.
Dimensiuni: 155 x 235 x 15 mm
Greutate: 0.48 kg
Ediția:2015
Editura: Springer International Publishing
Colecția Adis
Locul publicării:Cham, Switzerland
ISBN-10: 3319105264
Pagini: 120
Ilustrații: VII, 146 p. 1 illus. in color.
Dimensiuni: 155 x 235 x 15 mm
Greutate: 0.48 kg
Ediția:2015
Editura: Springer International Publishing
Colecția Adis
Locul publicării:Cham, Switzerland
Public țintă
Professional/practitionerCuprins
Introduction.- Pharmacology of Recommended Antimalarial Agents.- Drug Interaction Potential of Antimalarial Drugs Based on Known Metabolic Properties of Antimalarials.- Pharmacokinetic Drug Interactions Affecting Antimalarials.- Effects of Antimalarials on the Pharmacokinetics of Co-Administered Drugs.- Effects of Antimalarials on the Pharmacokinetics of Co-Administered Antimalarials.- Pharmacodynamic Interactions: Clinical Evidence for Combination Therapy, In Vitro Interactions, and In Vivo Interactions.- Limitations, Future Directions, and Conclusions.
Textul de pe ultima copertă
This comprehensive review provides a systematic, unbiased analysis, critique and summary of the available literature and generates novel clinical decision-making algorithms which can aid clinicians and scientists in practice management and research development. Potential mechanisms for the identified drug interactions are deduced from available preclinical and in vitro data which are interpreted in the context of the in vivo findings. Current limitations and gaps in the literature are summarized, and potential future research directions / experimentations are also suggested. In addition to the main objective to review the available clinical pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antimalarial drugs on the market today (i.e. chloroquine, amodiaquine, sulfadoxine, pyrimethamine, mefloquine, artemisinin, artemether, artesunate, dihydroartemisinin, artemotil, lumefantrine, primaquine, atovaquone, proguanil, piperaquine and quinine), this book also provides succinct chapter summaries on the epidemiology of malaria infection, diagnosis and therapeutics, in vivo pharmacology and chemistry, preclinical pharmacology, in vitro pharmacodynamics, in vitro reaction phenotyping, and in vitro drug-drug interaction data associated with the identified antimalarial drugs.
Caracteristici
Discusses the clinical pharmacokinetic and pharmacodynamic drug interactions involving antimalarial drugs recommended by the WHO Addresses the clinical significance of the interactions and provides a clinical decision making algorithm Covers potential mechanisms of the identified drug interactions using known pre-clinical human data