This book aims to explore the development model of Great Bay Area (GBA) of China as economic engine under the context of open policy. Based on comprehensive research, both theoretically and practically, on the leading free ports in the world and the regional development of well-known bay areas, it analyzes the challenges and opportunities of GBA synergetic free ports. A series of initiatives on the development of GBA synergetic free ports are proposed, including the synergy of space, industry, finance, technological innovation, institution, social governance, and personnel. Also, it ends with a system dynamic model to simulate the regional impact on GBA synergetic free ports, which indicates that economic development, trade, government finance, and population agglomeration would be improved significantly, in the GBA synergetic free ports scenario.