Megan, Waverly, Sidney, and Dominique are not necessarily four unique women but they share a very unique relationship. They each have a secret that, in spite of the strong foundation of their friendship, remains unknown. None of these women are who they appear to be, but after twenty years of knowing each other, secrets begin to emerge and things are turned upside down. Their lives, riddled with secrets, would have continued normally with none the wiser until circumstances change. Megan gives birth to two much-loved baby girls. Yet, at the same time, her mother swears she's not Megan's biological parent. As if that drama isn't enough, Megan's doctor tells her and her husband that their newborn baby girl, Nia, has the sickle cell trait. Waverly not only suspects her husband of cheating on her, but plans on demanding a divorce if her suspicions are true. Sidney and Dominique have problems of their own while they help their friends through difficult times. During this turmoil, skeletons come creeping out of closets. Lives are changed forever, and things will never be the same again for these four women.