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Computational Methods for Reproductive and Developmental Toxicology: QSAR in Environmental and Health Sciences

Editat de Donald R. Mattison
en Limba Engleză Paperback – 14 oct 2024
Building from the perspective of reproductive and developmental biology, Computational Methods for Reproductive and Developmental Toxicology provides a timely and comprehensive overview of approaches in reproductive and developmental toxicology.
The book, which is part of the QSAR in Environmental and Health Sciences series, is divided into three broad sections. The first provides a review of methods and approaches to meet the need for safety assessments in product development and regulatory approaches for environmental chemicals. The next one reviews the biological processes and endpoints involved in reproduction and development.
The final and largest section summarizes protocols for evaluating biological processes and endpoints within reproduction and development. It also discusses informatics resources and computational methods.
The book takes a cross-disciplinary approach bringing together developmental, reproductive and systems biology, chemistry, toxicology, pharmacology, biostatistics, information sciences, bioinformatics, and computational approaches. This valuable resource provides those in the field with the necessary knowledge to evaluate both classic and recent approaches to characterize toxicity.
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Specificații

ISBN-13: 9781032921891
ISBN-10: 1032921897
Pagini: 342
Ilustrații: 52
Dimensiuni: 156 x 234 mm
Greutate: 0.63 kg
Ediția:1
Editura: CRC Press
Colecția CRC Press
Seria QSAR in Environmental and Health Sciences

Locul publicării:Boca Raton, United States

Public țintă

Academic

Cuprins

INTRODUCTION. Introduction. Visions and Advancements for Meeting the Needs of Safety Assessment of Pharmaceutical and Industrial Chemicals. REACH and Environmental Chemicals.REPRODUCTION AND DEVELOPMENT: BIOLOGICAL PROCESSES AND ENDPOINTS. Female Reproductive Physiology. Maternal Recognition of Pregnancy. Early Embryo Development and Bipotential Gonad Formation. Assessing the Reproductive Health of Men with Occupational Exposures. REPRODUCTION AND DEVELOPMENT: BIOLOGICAL AND COMPUTATIONAL METHODS. Animal Study Protocols and Alternative Assays for the Assessment of Reproductive and Developmental Toxicity. US National Library of Medicine Resources for Computational Toxicology. Modeling Endocrine Regulation of the Menstrual Cycle Using Delay Differential Equations. Molecular Structural Characteristics That Influence Partitioning of Xenobiotics into Human Breast Milk. Approaches for Pediatric Developmental Drug-Induced Liver Injury. Adverse Outcome Pathways for Developmental Toxicity.

Notă biografică

Edited by

Donald R. Mattison, National Institutes of Health, Bethesda, Maryland, USA, and Risk Sciences International, Ottawa, Ontario, Canada

Descriere

Building from the perspective of reproductive and developmental biology, this book provides a timely and comprehensive overview of computational approaches in reproductive and developmental toxicology. It is divided into three broad sections. The first provides a review of methods and approaches to meet the need for safety assessments in