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Endocrine Disruption Modeling: QSAR in Environmental and Health Sciences

Editat de James Devillers
en Limba Engleză Paperback – 12 sep 2017
Uses Computational Tools to Simulate Endocrine Disruption Phenomena
Endocrine Disruption Modeling provides a practical overview of the current approaches for modeling endocrine activity and the related potential adverse effects they may induce on environmental and human health. Based on the extensive research of an international panel of contributors from industry, academia, and regulatory agencies, this is the first book devoted to using computer tools to better understand and simulate the multifaceted aspects of endocrine disruption in humans and wildlife.
Explores Diverse Modeling Techniques and Applications
This up-to-date resource focuses on xenobiotics that are accidentally released into the environment with the potential to disturb the normal functioning of the endocrine system of invertebrates and vertebrates but also on the specific agro-chemistry design of chemicals that take control of insect endocrine systems. A comprehensive research reference, Endocrine Disruption Modeling provides a collection of computational strategies to model these structurally diverse chemicals. It concludes with a review of the available e-resources in the field, rounding out the book’s task-oriented approach to future EDC discovery.
Endocrine Disruption Modeling is the first book in the QSAR in Environmental and Health Sciences series (James Devillers, j.devillers@ctis.fr).
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Specificații

ISBN-13: 9781138111912
ISBN-10: 1138111910
Pagini: 424
Ilustrații: 25-50 equations; 100 Illustrations, black and white
Dimensiuni: 156 x 234 x 26 mm
Greutate: 0.79 kg
Ediția:1
Editura: CRC Press
Colecția CRC Press
Seria QSAR in Environmental and Health Sciences

Locul publicării:Boca Raton, United States

Public țintă

Professional

Cuprins

In Silico Methods for Modeling Endocrine Disruption. Mechanisms of Endocrine Disruptions, A Tentative Overview. Population Dynamics Modeling: A Tool For Environmental Risk Assessment of Endocrine Disrupting Chemicals. Application of Pharmacokinetic Modeling to Understand the Mechanism of Action of Endocrine Disrupting Chemicals. Comparative Modeling Review of Nuclear Hormone Receptor Superfamily. The FDA’s Endocrine Disruptor Knowledge Base (EDKB): Lessons Learned in QSAR Modeling and Applications. A Structure-Activity Relationship (SAR) Analysis for the Identification of Environmental Estrogens: The Categorical-SAR (cat-SAR) Approach. Kohonen and Counterpropagation Neural Networks Employed for Modeling Endocrine Disruptors. Quantitative Spectrometric Data-Activity Relationships (QSDAR) Models of Endocrine Disruptor Binding Activities. Mechanism-Based Modeling of Estrogen Receptor Binding Affinity: A COREPA Implementation. Molecular Field Analysis Methods for Modeling Endocrine Disruptors. Structure-Activity Modeling of a Diverse Set of Endrogen Receptor Ligands. SAR and QSAR Analyses of Substituted Dibenzoylhydrazines for Their Mode of Action as Ecdysone Agonists. e-Endocrine Disrupting Chemical Databases for Deriving SAR and QSAR Models.

Descriere

Based on the research of an international panel of contributors from industry, academia, and regulatory agencies, this book provides an excellent overview of approaches for modeling the endocrine activity of chemicals and the related potential adverse effects they may induce on environmental and human health. It focuses on chemicals accidentally released into the environment and also on the specific design, in agro-chemistry, of chemicals acting on the endocrine system of insects to control them. An interesting feature of the book is the bringing together of these two aspects of endocrine disruption, which are based on the same modeling concepts. It includes a review of available e-resources.