Computer Techniques in Preclinical and Clinical Drug Development
Autor Robert C. Jacksonen Limba Engleză Paperback – 7 oct 2019
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Specificații
ISBN-13: 9780367401283
ISBN-10: 0367401282
Pagini: 256
Dimensiuni: 156 x 234 x 14 mm
Greutate: 0.45 kg
Ediția:1
Editura: CRC Press
Colecția CRC Press
ISBN-10: 0367401282
Pagini: 256
Dimensiuni: 156 x 234 x 14 mm
Greutate: 0.45 kg
Ediția:1
Editura: CRC Press
Colecția CRC Press
Public țintă
Academic and Professional Practice & DevelopmentCuprins
Introduction: The Preclinical and Clinical Drug Development Process Physiological Pharmacokinetic Modeling Interspecies Scaling Prediction of Drug Metabolism and Toxicity Pharmacodynamic Modeling Cytokinetic Modeling Prediction of Drug Resistance Conclusions: The Virtual Clinical Trial References Appendix: Computational Pharmacology Software Suppliers Abbreviations Index
Descriere
It is estimated that 80 to 90% of drugs under development never make it to the marketplace due to a number of factors that should be, at least partially, predictable from preclinical testing. Computer Techniques in Preclinical and Clinical Drug Development asks the question, "How can we use computational methods to improve the success rate in drug development?" It shows how modeling makes it possible to extract the maximum amount of information and predictive value from preclinical data. Computer modeling methods from the areas of pharmacokinetics, pharmacodynamics, cytokinetics, and inhibition kinetics of multi-enzyme pathways are all discussed in this unique reference source.
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