Historical research in previous decades has done a great deal to explore the social and political context of early modern natural and moral inquiries. Particularly since the publication of Steven Shapin and Simon Schaffer’s Leviathan and the Air-Pump (1985) several studies have attributed epistemological stances and debates to clashes of political and theological ideologies. The present volume suggests that with an awareness of this context, it is now worth turning back to questions of the epistemic content itself. The contributors to the present collection were invited to explore how certain non-epistemic values had been turned into epistemic ones, how they had an effect on epistemic content, and eventually how they became ideologies of knowledge playing various roles in inquiry and application throughout early modern Europe.