Current Topics in Nonclinical Drug Development: Volume 2: Current Topics in Nonclinical Drug Development Series
Editat de Philip Bentley, Pritam S. Sahota, Zbigniew Wojcinskien Limba Engleză Hardback – 9 noi 2023
Select topics include:
- Evolution of Artificial Intelligence (AI) technologies and the impact on toxicologic pathology.
- Current approaches to carcinogenicity testing.
- Predicting drug-drug interactions.
- Current understanding of idiosyncratic drug reaction.
- Assessing cardiovascular risks beyond QT interval.
- Use of 3D cell cultures in toxicology and ADME.
- Development of small molecule-antibody complexes.
- Differentiating adverse from non-adverse findings in nonclinical studies.
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Specificații
ISBN-13: 9780367466688
ISBN-10: 0367466686
Pagini: 487
Ilustrații: 33 Tables, black and white; 18 Line drawings, color; 26 Line drawings, black and white; 21 Halftones, color; 1 Halftones, black and white; 39 Illustrations, color; 27 Illustrations, black and white
Dimensiuni: 156 x 234 x 28 mm
Greutate: 1.02 kg
Ediția:1
Editura: CRC Press
Colecția CRC Press
Seria Current Topics in Nonclinical Drug Development Series
ISBN-10: 0367466686
Pagini: 487
Ilustrații: 33 Tables, black and white; 18 Line drawings, color; 26 Line drawings, black and white; 21 Halftones, color; 1 Halftones, black and white; 39 Illustrations, color; 27 Illustrations, black and white
Dimensiuni: 156 x 234 x 28 mm
Greutate: 1.02 kg
Ediția:1
Editura: CRC Press
Colecția CRC Press
Seria Current Topics in Nonclinical Drug Development Series
Public țintă
Professional ReferenceNotă biografică
Pritam S. Sahota, PhD, studied for his Veterinary Medicine (BVSc) and Veterinary Pathology (MVSc and PhD) degrees at Punjab Agricultural University in India. He is a Diplomate of the American Board of Toxicology. After completing his PhD, he immigrated to the USA in 1976 and worked for Dawson Research Corporation in Orlando, Florida for 10 years with increasing responsibilities as Toxicologic Pathologist, Senior Toxicologic Pathologist, and Scientific Director. Since 2012, Dr. Sahota has been President of Global ToxPath LLC (Toxicologic Pathology Consultancy) located in Kennewick, WA.
Philip Bentley, PhD, is Principal Consultant at Toxicodynamix International LLC. He studied biochemistry at the University of Hull, UK, graduating with a BSc in 1970 and a PhD in 1974. He had postdoctoral fellowships at the Universities of Basel. Switzerland and Mainz, Germany. He has authored more than 80 scientific publications, has lectured in toxicology at the University of Basel for more than 30 years, and is a past President of the European Society of Biochemical Pharmacology and the Swiss Society of Toxicology.
Zbigniew W. Wojcinski, DVM, DVSc is President of Toxicology & Pathology Consulting, LLC, in Hillsborough, NC and has over 35 years’ experience in pharmaceutical drug development. Dr. Wojcinski earned his undergraduate degree (BSc) in Zoology from the University of Toronto and his DVM and DVSc (Pathology) degrees from the Ontario Veterinary College, University of Guelph. He is a certified Diplomate of the American Board of Toxicology and a Diplomate of the American College of Veterinary Pathologists.
Philip Bentley, PhD, is Principal Consultant at Toxicodynamix International LLC. He studied biochemistry at the University of Hull, UK, graduating with a BSc in 1970 and a PhD in 1974. He had postdoctoral fellowships at the Universities of Basel. Switzerland and Mainz, Germany. He has authored more than 80 scientific publications, has lectured in toxicology at the University of Basel for more than 30 years, and is a past President of the European Society of Biochemical Pharmacology and the Swiss Society of Toxicology.
Zbigniew W. Wojcinski, DVM, DVSc is President of Toxicology & Pathology Consulting, LLC, in Hillsborough, NC and has over 35 years’ experience in pharmaceutical drug development. Dr. Wojcinski earned his undergraduate degree (BSc) in Zoology from the University of Toronto and his DVM and DVSc (Pathology) degrees from the Ontario Veterinary College, University of Guelph. He is a certified Diplomate of the American Board of Toxicology and a Diplomate of the American College of Veterinary Pathologists.
Cuprins
1. Introduction and History of Digital Toxicologic Pathology 2. Carcinogenicity Testing of Human Pharmaceuticals 3. Differentiating Adverse and Non-adverse Findings in Nonclinical Studies 4. Current Understanding of Idiosyncratic Drug Reactions 5. Three-Dimensional Cell Culture Models in Toxicology and ADME 6. Assessing Cardiovascular Risk Beyond the hERG Channel and the QT Interval 7. Fundamentals of Drug-Drug Interactions 8. Development of Small Molecule-Antibody Complexes
Descriere
Written by a variety of experts in the field, this book explores the critical issues and current topics in nonclinical drug development. It covers individual topics and strategies in drug development from compound characterization to drug registration.