Current Trends in Histocompatibility de Ralph Reisfeld

Current Trends in Histocompatibility: Volume 2 Biological and Clinical Concepts

Ralph Reisfeld

en Limba Engleză Paperback – 16 sep 2012

Information about histocompatibility antigens is expanding so rapidly that of all advances. In these volumes, we have it is difficult to remain abreast made an effort to bring together the most current work on topics that have generated most of the recent advances and discussions. We have asked each author to present and interpret his most current work, and we have judiciously refrained from imposing our own prejudices and viewpoints. Although there is obvious overlap in some individual topics, we have encouraged this to provide the reader with as many different and some times opposing viewpoints as possible. This approach will, we hope, give a broad overview of current ideas in the field. We wish to thank all contributors for their timely and exciting manu scripts, and we sincerely hope that the reader will benefit from these volumes. R. A. Reisfeld S. Ferrone La Jolla vii Contents I. Role of Histocompatibility Antigens in Cell-Cell Interaction Chapter 1 Histocompatibility Antigens and the T-Cell Repertoire . . . . . . . . . . . . . . 3 Harald von Boehmer 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. H-2 Restriction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 1. H-2 Restriction of T Cells. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 2. B Cells Are Not H-2-Restricted . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 3. H-2-Linked Ir Genes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 3. 1. Influence on the T-Cell Repertoire . . . . . . . . . . . . . . . . . . . . . . . . 5 3. 2. H-2-Gene Complementation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 3. 3. TheB-Cell Repertoire Is Not Directly Influenced by H-2-Linked Ir Genes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 4. Frequency of Cells Specific for Allogeneic H-2 Antigens . . . . . . . . 12 4. 1. Allospecific T Cells. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 4. 2. Allospecific B Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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Cuprins

I. Role of Histocompatibility Antigens in Cell-Cell Interaction.- 1 Histocompatibility Antigens and the T-Cell Repertoire.- 2 Continuously Proliferating Allospecific T-Cell Lines: A Model to Study T-Cell Functions and Receptors.- 3 The Dual Specificity of Virus-Immune T Cells: Functional Indications That Virus and H-2 Molecules May Associate on the Cell Membrane.- 4 Hapten Recognition by Cytotoxic T Cells: The Modifying Influence of the Major Histocompatibility Complex.- 5 New Thoughts on the Control of Self-Recognition, Cell Interactions, and Immune Responsiveness by Major Histocompatibility Complex Genes.- 6 The Role of Cell-Surface Antigens in Progressive Tumor Growth (Immunological Surveillance Re-revisited).- 7 Self-HLA-D-Region Products Restrict Human T-Lymphocyte Activation by Antigen.- 8 How Strict is the MHC Restriction of T Cells?.- II. Clinical Aspects of Transplantation: Association with Disease.- 9 The Role of Histocompatibility Antigens in Clinical Transplantation.- 10 HLA-Linked Regulation of Immune Responsiveness in Man: Role of I-Region-Gene Products.- 11 Clinical Histocompatibility Testing in Renal Transplantation: Potential Keys to Alloimmune Specificity and Reactivity.- 12 Human Ia-like Alloantigens and Their Medical Significances.- 13 The Enigma of Good Kidney-Graft Survival in the Face of Poor HLA Matches: HLA Matching for Kidney Transplantation Makes Sense.- 14 Histocompatibility Antigens and Susceptibility to Disease—Genetic Considerations.