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Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules: The Shape of Organic Synthesis to Come de Yuichi Kobayashi

Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules: The Shape of Organic Synthesis to Come

Editat de Yuichi Kobayashi
en Limba Engleză Paperback – 15 aug 2020
This book describes cutting-edge organic syntheses of biologically active compounds, isolation of pharmaceutically promising compounds from microorganisms, drug design, and progress on chemical biology. Synthetic strategy and tactics are summarized for super-carbon chain compounds, antitumor polycycles, aryl C-glycoside, antimycins, duocarmycins, cannabinoids, and other compounds. Special chapters are devoted to synthesis and biochemistry of fatty acid metabolites, which play a central role in the initiation and resolution of inflammation. The book provides a quick survey of trending topics in organic synthesis and chemical tools for biological investigation, and furnishes ideas for future research in organic synthesis. In addition, the contents can easily be understood by young chemists, graduate students, and those who are looking for new research based on organic chemistry.

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Specificații

ISBN-13: 9789811362460
ISBN-10: 9811362467
Pagini: 355
Ilustrații: XXV, 355 p. 406 illus., 127 illus. in color.
Dimensiuni: 155 x 235 mm
Ediția:1st ed. 2019
Editura: Springer Nature Singapore
Colecția Springer
Locul publicării:Singapore, Singapore

Cuprins

1. Microbial Fraction Library: A Screening Source for Drug Discovery.- 2. Efficient Total Synthesis of Ōmura Natural Products.- 3. Enantioselective Total Synthesis of the Antitumor Polycyclic Natural Products, FR182877 and Taxol.- 4. Synthetic Approaches on the Pluramycin-class Antibiotics.- 5. Recent Progress Toward the Total Synthesis of Duocarmaycins A and SA, Yatakemaycin, and PDE-I and –II.- 6. Structure-Activity Relationship Studies of Maitotoxin Based on Chemical Synthesis.- 7. Substitution of Allylic Picolinates with Various Copper Reagents and Synthetic Applications.- 8. Total Synthesis of Ingenol.- 9. Strategies for Synthesis of Anti-inflammatory Metabolites of Unsaturated Fatty Acids.- 10. Biosynthesis, biological functions, and receptors of leukotriene B4 and 12(S)-hydroxyheptadecatrienoic acid.- 11. Synthesis of classical/non-classical hybrid cannabinoids and related compounds.- 12. Exploring bioactive marine natural products and identification of their molecular targets.- 13. Target protein chemical modification.- 14. Target Identification of Bioactive Compounds by Photoaffinity Labeling Using Diazido Probes

Notă biografică

Yuichi KOBAYASHI received Ph.D. from the Tokyo Institute of Technology in 1981. His supervisors were Professors Jiro Tsuji and Fumie Sato at the Tokyo Institute of Technology and Gibert Stork at Columbia University. He is a full Professor at Tokyo Institute of Technology. His research interests include organic synthesis using transition metal catalysts and developments of chiral C–C bond formation. Targets include fatty acid metabolites known as resolvins and leukotrienes, isoprostanes, epi-jasmonates, tetrahydrocannabinoids, cinchona alkaloids, phoslactomycins, etc. The picolinoxy leaving group in allylic substitution has created tertially and quaternary carbons. These achievements have been published in internationally renowned journals such as Angew. Chem. Int. Ed., Org. Lett., Nature, Chem. Eur. J. He has 35 years of teaching experience at the Tokyo Institute of Technology. 

Textul de pe ultima copertă

This book describes cutting-edge organic syntheses of biologically active compounds, isolation of pharmaceutically promising compounds from microorganisms, drug design, and progress on chemical biology. Synthetic strategy and tactics are summarized for super-carbon chain compounds, antitumor polycycles, aryl C-glycoside, antimycins, duocarmycins, cannabinoids, and other compounds. Special chapters are devoted to synthesis and biochemistry of fatty acid metabolites, which play a central role in the initiation and resolution of inflammation. The book provides a quick survey of trending topics in organic synthesis and chemical tools for biological investigation, and furnishes ideas for future research in organic synthesis. In addition, the contents can easily be understood by young chemists, graduate students, and those who are looking for new research based on organic chemistry.

Caracteristici

Presents a quick survey of topics in organic synthesis for top researchers, young chemists, graduate students, and those looking for new research based on organic chemistry Suggests future research based on organic synthesis Enables understanding of the purpose and major results of the contents with schemes and illustrations