This book constitutes the thoroughly refereed post-conference proceedings of the Second International Conference on Data Engineering and Management, ICDEM 2010, held in Tiruchirappalli, India, in July 2010.The 46 revised full papers presented together with 1 keynote paper and 2 tutorial papers were carefully reviewed and selected from numerous submissions. The papers are organized in topical sections on Digital Library; Knowledge and Mulsemedia; Data Management and Knowledge Extraction; Natural Language Processing; Workshop on Data Mining with Graphs and Matrices.