Petroleum emulsion occurs at many stages in the production and treatment of crude oil. One ways to solve this problem is to create synergetic composition of demulsifiers. The objective of this work is to develop synergetic compositions of demulsifiers based on surfactants Reapon-4B™. The target is to achieve higher efficiency, and analyze the composition; flow parameters; characteristics; and the mechanical and acoustic effect under intensity and rotation speed of the rotary pulsation apparatus RPA. This book contains five chapters which respectively containing relative topics. Chapter 1 contains background and scopes. The principals of dehydration and desalinization processes, emulsion formation, demulsification mechanism, surface active properties, and efficiency of demulsifiers are presented in chapter 2. The experimental part are discussed in chapter 3. The analysis of composite demulsifiers impact onto the flow properties of oil are noticed in chapter 4. Analysis of emulsion using RPA are presented in chapter 5, this chapter deal with the qualitative view of emulsion breaking, analysis of the composite demulsifiers impact, and flow properties of oil emulsions using RPA.