This concise manual offers best practice guidance on dental treatment of pediatric patients with special health care needs (CSHCN). The straightforward approaches described will enable clinicians to deliver high-quality, patient-centered care to children with intellectual and developmental disabilities. Readers will find up-to-date information on case-based treatment planning, alternative caries management strategies, the use of behavioral and pharmacological interventions to facilitate delivery of quality treatment, and a team approach to care. Practical clinical tips are provided on how to achieve and maintain oral health, including good oral hygiene and nutrition. A systematic framework for patient assessment and interaction with medical colleagues will assist readers in understanding when dental protocols must be altered. Other important topics include techniques for effective communication with CSHCN, behavioral strategies to improve treatment acceptance, the role of occupational therapy techniques, the sensory adapted dental environment, and the use protective stabilization.