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Design and Analysis of Animal Studies in Pharmaceutical Development de Shein-Chung Chow

Design and Analysis of Animal Studies in Pharmaceutical Development: Chapman & Hall/CRC Biostatistics Series

Editat de Shein-Chung Chow, Jen-pei Liu
en Limba Engleză Paperback – 30 iun 2020
"Provides well-integrated, comprehensive coverage of all the major statistical designs and methods used for animal studies in pharmaceutical research and development. Demonstrates the correct way to interpret the results of animal studies in the risk assessment of biopharmaceutical products and clarifies detailed presentations with real-world examples. "
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Specificații

ISBN-13: 9780367579388
ISBN-10: 0367579383
Pagini: 420
Dimensiuni: 152 x 229 mm
Greutate: 0.45 kg
Ediția:1
Editura: CRC Press
Colecția Chapman and Hall/CRC
Seria Chapman & Hall/CRC Biostatistics Series

Locul publicării:Boca Raton, United States

Public țintă

Professional

Cuprins

Experimental design principles for animal studies in pharmaceutical development; interval estimation with small samples for Median Lethal Dose (LD50) or Median Effective Dose (ED50); principles in statistical testing in randomized toxicological studies; subacute toxicity studies - proof of safety versus proof of hazard; design of long-term carcinogenicity studies; analysis of long-term carcinogenicity studies; design of reproductive studies; analysis of reproductive and development studies; the in vitro Ames tests; the in vitro Chinese hamster ovary cell mutagenesis studies.

Recenzii

". . .This book series will provide comprehensive and unified presentations of statistical designs and analyses of important applications in biostatistics. . .A well-balanced summary will be given of current and recently developed statistical methods and interpretations for both statisticians and researchers/scientists with minimal statistical knowledge who are engaged in applied biostatistics. The series is committed to providing easy-to-understand state-of-the-art references and textbooks. In each volume statistical concepts and methodologies will be illustrated with real examples. "
---Shein-Chung Chow, Series Editor
". . .a fine overview of material that an industrial statistician will need to know when seeking employment in preclinical areas of pharmaceutical research. "
---Technometrics

Descriere

"Provides well-integrated, comprehensive coverage of all the major statistical designs and methods used for animal studies in pharmaceutical research and development. Demonstrates the correct way to interpret the results of animal studies in the risk assessment of biopharmaceutical products and clarifies detailed presentations with real-world examp