Cantitate/Preț
Produs
Total produse
Vezi coșul
Single-Arm Phase II Survival Trial Design de Jianrong Wu

Single-Arm Phase II Survival Trial Design: Chapman & Hall/CRC Biostatistics Series

Autor Jianrong Wu
en Limba Engleză Paperback – 24 iul 2023
Single-Arm Phase II Survival Trial Design provides a comprehensive summary to the most commonly- used methods for single-arm phase II trial design with time-to-event endpoints. Single-arm phase II trials are a key component for successfully developing advanced cancer drugs and treatments, particular for target therapy and immunotherapy in which time-to-event endpoints are often the primary endpoints. Most test statistics for single-arm phase II trial design with time-to-event endpoints are not available in commercial software.
Key Features:
  • Covers the most frequently used methods for single-arm phase II trial design with time-to-event endpoints in a comprehensive fashion.
  • Provides new material on phase II immunotherapy trial design and phase II trial design with TTP ratio endpoint.
  • Illustrates trial designs by real clinical trial examples
  • Includes R code for all methods proposed in the book, enabling straightforward sample size calculation.
Citește tot Restrânge

Toate formatele și edițiile

Toate formatele și edițiile Preț Express
Paperback (1) 35722 lei  3-5 săpt. +2477 lei  7-13 zile
  CRC Press – 24 iul 2023 35722 lei  3-5 săpt. +2477 lei  7-13 zile
Hardback (1) 109278 lei  6-8 săpt.
  CRC Press – 20 iul 2021 109278 lei  6-8 săpt.

Din seria Chapman & Hall/CRC Biostatistics Series

  • Interface between Regulation and Statistics in Drug Development
    Preț: 35448 lei
  • 9% Bayesian Precision Medicine
    Preț: 64304 lei
  • 5% Hybrid Frequentist/Bayesian Power and Bayesian Power in Planning Clinical Trials
    Preț: 33101 lei
  • Joint Models for Longitudinal and Time-to-Event Data: With Applications in R
    Preț: 34142 lei
  • Bayesian Methods in Pharmaceutical Research
    Preț: 36200 lei
  • Bayesian Adaptive Methods for Clinical Trials
    Preț: 35065 lei
  • 9% Causal Inference in Pharmaceutical Statistics
    Preț: 64152 lei
  • Cure Models: Methods, Applications, and Implementation
    Preț: 28880 lei
  • Applied Meta-Analysis with R and Stata
    Preț: 35663 lei
  • Sample Size Calculations in Clinical Research
    Preț: 31141 lei
  • 9% Estimands, Estimators and Sensitivity Analysis in Clinical Trials
    Preț: 72920 lei
  • 9% Quantitative Methods for Precision Medicine: Pharmacogenomics in Action
    Preț: 60832 lei
  • Signal Detection for Medical Scientists: Likelihood Ratio Test-based Methodology
    Preț: 35663 lei
  • Real-World Evidence in Drug Development and Evaluation
    Preț: 35477 lei
  • 8% Statistical Thinking in Clinical Trials
    Preț: 37664 lei
  • Real-World Evidence in a Patient-Centric Digital Era
    Preț: 34837 lei
  • 9% Controlled Epidemiological Studies
    Preț: 80131 lei
  • Structural Equation Modeling for Health and Medicine
    Preț: 34289 lei
  • 9% Statistical Methods for Dynamic Disease Screening and Spatio-Temporal Disease Surveillance
    Preț: 64331 lei
  • 9% ROC Analysis for Classification and Prediction in Practice
    Preț: 64457 lei
  • 9% Statistical Design, Monitoring, and Analysis of Clinical Trials: Principles and Methods
    Preț: 59430 lei
  • 9% Value of Information for Healthcare Decision-Making
    Preț: 73199 lei
  • 9% Innovative Methods for Rare Disease Drug Development
    Preț: 83328 lei
  • Confidence Intervals for Discrete Data in Clinical Research
    Preț: 35903 lei
  • Bayesian Analysis with R for Drug Development: Concepts, Algorithms, and Case Studies
    Preț: 31141 lei
  • 9% Analysis of Incidence Rates
    Preț: 94038 lei
  • 18% Design and Analysis of Clinical Trials for Predictive Medicine
    Preț: 77781 lei
  • 18% Bayesian Methods in Health Economics
    Preț: 69467 lei
  • 18% Medical Biostatistics
    Preț: 170105 lei
  • 26% Dose Finding by the Continual Reassessment Method
    Preț: 87513 lei
  • 18% Design and Analysis of Bridging Studies
    Preț: 77237 lei
  • 25% Statistics In the Pharmaceutical Industry
    Preț: 82563 lei
  • 15% Fundamental Concepts for New Clinical Trialists
    Preț: 66672 lei
  • 25% Statistical Methods for Drug Safety
    Preț: 55758 lei
  • 25% Randomization, Masking, and Allocation Concealment
    Preț: 62583 lei
  • 18% Quantitative Methods for HIV/AIDS Research
    Preț: 77312 lei
  • 25% Design and Analysis of Bioavailability and Bioequivalence Studies
    Preț: 77807 lei
  • 25% Exposure-Response Modeling: Methods and Practical Implementation
    Preț: 62829 lei
  • 18% Modern Adaptive Randomized Clinical Trials: Statistical and Practical Aspects
    Preț: 110598 lei
  • 25% Handbook of Regression and Modeling: Applications for the Clinical and Pharmaceutical Industries
    Preț: 88755 lei
  • 25% Randomized Phase II Cancer Clinical Trials
    Preț: 52681 lei
  • 25% Applied Biclustering Methods for Big and High-Dimensional Data Using R
    Preț: 56034 lei
  • 15% Adaptive Design Theory and Implementation Using SAS and R
    Preț: 47633 lei
  • 18% Monte Carlo Simulation for the Pharmaceutical Industry: Concepts, Algorithms, and Case Studies
    Preț: 100045 lei
  • 18% Patient-Reported Outcomes: Measurement, Implementation and Interpretation
    Preț: 109667 lei

Preț: 35722 lei

Nou

Puncte Express: 536
Preț estimativ în valută:
6840€ • 7056$ • 5669£

Carte disponibilă

Livrare economică 30 ianuarie-13 februarie
Livrare express 16-22 ianuarie pentru 3476 lei

 Adaugă în coș

Wish list
Gift list
Am citit!
Adaugă în listă
Preluare comenzi: 021 569.72.76

Specificații

ISBN-13: 9780367653491
ISBN-10: 0367653494
Pagini: 273
Ilustrații: 58
Dimensiuni: 156 x 234 x 17 mm
Greutate: 0.51 kg
Ediția:1
Editura: CRC Press
Colecția Chapman and Hall/CRC
Seria Chapman & Hall/CRC Biostatistics Series

Cuprins

1. Introduction of Single-Arm Phase II Trial Design
2. Phase II Trial Design Under Parametric Model
3. One-Stage Design Evaluating Survival Probabilities
4. Two-Stage Design Evaluating Survival Probabilities
5. One-Stage Design Evaluating Survival Distributions
6. Two-Stage Design Evaluating Survival Distributions
7. Phase II Immunotherapy Trial Design
8. Phase II Trial Design with GMI Endpoint
9. Bayesian Single-Arm Phase II Trial Design
Appendix A. Probability of Failure Under Uniform Accrual
Appendix B. Asymptotic Distribution of Nelson-Aalen Estimate of the Cumulative Hazard
Appendix C. Derivation Asymptotic Distribution of the OSLRT
Appendix D. Derivation of equations (6.8) and (6.9)
Appendix E. Crossing point for the mixture cure model
Appendix F. Derivation asymptotic distribution of the score test Q
Appendix G. Generate random variables from GBVE model
Appendix H. Derivation censoring survival distribution of GMI
Appendix I. Proof of monotonicity of the posterior probability
Appendix J. Relationship between frequentist and Bayesian type I error rates
Appendix K. R Code

Notă biografică

Jianrong (John) Wu is a professor in the Division of Cancer Biostatistics, Department of Internal Medicine, University of Kentucky; Biostatistics and Bioinformatics Shared Resource, Markey Cancer Center. Dr. Wu has more than 20 years’ experience of designing and conducting cancer clinical trials at St. Jude Children’s Research Hospital and Markey Cancer Center and has developed many novel statistical methods for designing and monitoring single-arm phase II and randomized phase III trial design with time-to-event endpoints.

Recenzii

"I would say it is a great book, great summary of not so common and widely available methods, focusing for a statistical audience with strong statistical skills."
David Manteigas, Portugal, ISCB News, June 2022.

Descriere

Single-arm phase II trial is a key component for developing advanced cancer drug and treatment to target therapy and immunotherapy in which time-to-event endpoints are the primary endpoints. The proposed book provides a comprehensive summary to the most commonly used methods for single-arm phase II trial design with time-to-event endpoints.