Drug Absorption at Different Regions of the Human Gastro-Intestinal Tract: Methods of Investigation and Results / Arzneimittelabsorption aus verschiedenen Bereichen des Gastrointestinaltraktes beim Menschen: Untersuchungsmethoden und Ergebnisse: Proceedings of an International Workshop on Methods in Clinical Pharmacology Frankfurt, November 14, 1986 / Vorträge und Diskussionen auf einem Internationalen Workshop „Methods in Clinical Pharmacology” Frankfurt, 14. November 1986: Methods in clinical pharmacology, cartea 7

Contents/Inhaltsverzeichnis.- Eröffnung und Themeneinführung.- Intubation techniques for the study of the absorption of drugs in man.- Simultaneous pharmacokinetic and in vivo gamma scintigraphic monitoring in the development of an enprofylline SR-tablet.- In Vivo Dissolution and Absorption Kinetics of Sustained -Release Theophylline, Studied with Stable Isotope Methodology.- Course of Development of the HF-capsule, variations and method related typical findings.- Evaluation of the colonic drug absorption in patients with an artificial intestinal stoma and by colonoscopy in normal volunteers.- Theophyllin. Absorption in verschiedenen Darmabschnitten.- Indication of Absorption of Theophylline from the Large Intestine following Administration of Depot Preparations.- Impaired Bioavailability of Theophylline Retard Preparations as a Result of pH-dependent Drug Release Rates.- Lokalisation der Absorption von Furosemid. Befunde und Folgerungen für verschiedene Darreichungsformen.- Absorption of Isosorbide-5-nitrate from the Gastrointestinal Tract.- Gastrointestinal Absorption of Drugs: Physico-chemical and biomathematical Aspects.- Absorption of Hexobarbital and Caffeine in Patients with liver cirrhosis.- Influence of Absorption Rate on the MetaboHc Kinetics of Theophylline.- Metabolism of Fosfestrol by intestinal mucosa.- Drug input rate from the Gl-tract, Michaelis-Menten kinetics and the bioavailability of Slow-Release Verapamil and Nifedipine.- Absorption of Caffeine in Patients with Gastric Stasis and after partial gastrectomy (BILLROTH II).- Round table-discussion.- Schlußwort.