Drug Delivery Across Physiological Barriers
Editat de Silvia Muroen Limba Engleză Hardback – 6 apr 2016
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Specificații
ISBN-13: 9789814669405
ISBN-10: 9814669407
Pagini: 426
Ilustrații: 51
Dimensiuni: 152 x 229 x 29 mm
Greutate: 0.74 kg
Ediția:1
Editura: Jenny Stanford Publishing
Colecția Jenny Stanford Publishing
ISBN-10: 9814669407
Pagini: 426
Ilustrații: 51
Dimensiuni: 152 x 229 x 29 mm
Greutate: 0.74 kg
Ediția:1
Editura: Jenny Stanford Publishing
Colecția Jenny Stanford Publishing
Public țintă
Academic and PostgraduateCuprins
Introduction. Physiological Barriers Controlling Penetration and Transport of Substances in the Body. Structure and function of epithelial and endothelial barriers. The plasma membrane as a semipermeable barrier. Biology and regulation of protein sorting and vesicular transport. Pathogens and intracellular transport. Strategies for Drug Penetration across Tissue Compartments. Drug transport across the skin. Mucosal barriers. Transport of therapeutics across the gastrointestinal epithelium. Crossing the endothelial barrier. Nanoparticle-based drug delivery to solid tumors. Drug Transport into Cells and Subsequent Intracellular Trafficking. Membrane lipids and drug transport. Drug delivery systems that fuse with the plasmalemma. Endocytosis and the endolysosomal route in drug delivery. Endo-lysosomal escape. Intracellular transport to the mitochondria and other organelles.
Notă biografică
Silvia Muro is an associate professor in the Institute for Bioscience and Biotechnology Research and the Department of Bioengineering, University of Maryland, USA. She obtained her PhD in sciences (molecular biology) from Universidad Autónoma de Madrid, Spain. She received a postdoctoral training in drug delivery and obtained a research assistant professor position in the Pharmacology Department at the University of Pennsylvania, USA. Her research focuses on targeting and transport of nanomedicines into and across cells, with emphasis on delivery of biological therapeutics for treatment of inherited enzyme deficiencies. Her work has received awards from the Controlled Release Society, the American Society for Nanomedicine, and others, and since 2012 she is a standing member of the Nanotechnology Study Section [NANO] of the USA National Institute of Health.
Recenzii
"This book combines a thorough overview of the barriers encountered and strategies employed to increase the delivery of therapeutics. It also provides a critical assessment of the merits and limitations of delivery approaches. Overall, this is a concentrate of the most recent scientific discoveries written by highly recognized authors in the field. It is an excellent reference for both students and seasoned scientists."
—Dr. Mohamed ElSayed, University of Michigan, USA
"Drug delivery across physiological barriers is a historic and challenging problem. This compelling book addresses this topic thoroughly, with detailed chapters ranging from descriptions of the composition of physiological barriers, through barrier-penetrating drug delivery strategies to how drugs are trafficked once inside cells. A must-have addition to any pharmaceutical scientist’s technical library."
—Dr. John D. Higgins, Merck & Co., USA
"Drug Delivery Across Physiological Barriers is a fundamental book in nanomedicine, particularly for those who start in the field of designing therapeutic strategies based on nano-drug delivery systems. It addresses the challenging anatomical and pathological barriers of the epithelia, endothelia, extracellular matrix, and cell endocytic pathways. It shows that a thorough understanding of the stepwise processing to which nanostructures are exposed throughout the body and intracellularly is a critical tool for a wise design of nanomedicines."
—Dr. Eder L. Romero, National University of Quilmes, Argentina
—Dr. Mohamed ElSayed, University of Michigan, USA
"Drug delivery across physiological barriers is a historic and challenging problem. This compelling book addresses this topic thoroughly, with detailed chapters ranging from descriptions of the composition of physiological barriers, through barrier-penetrating drug delivery strategies to how drugs are trafficked once inside cells. A must-have addition to any pharmaceutical scientist’s technical library."
—Dr. John D. Higgins, Merck & Co., USA
"Drug Delivery Across Physiological Barriers is a fundamental book in nanomedicine, particularly for those who start in the field of designing therapeutic strategies based on nano-drug delivery systems. It addresses the challenging anatomical and pathological barriers of the epithelia, endothelia, extracellular matrix, and cell endocytic pathways. It shows that a thorough understanding of the stepwise processing to which nanostructures are exposed throughout the body and intracellularly is a critical tool for a wise design of nanomedicines."
—Dr. Eder L. Romero, National University of Quilmes, Argentina
Descriere
For most therapeutics, the targets of action are intracellular and/or require penetration across cellular and tissue layers. The design of strategies capable of controlling the transport of therapeutic agents through these physiological barriers has, hence, become an imperative and yet challenging need in the quest for better therapeutics. This book provides an overview of the current advances in this field from multiple perspectives, including considerations on the biological regulation and natural mechanisms overcoming these barriers, as well as drug delivery strategies facilitating the transport of drugs and their carriers at the tissue, cell, and subcellular levels.