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Drug Discovery Strategies and Methods

Autor Alexandros Makriyannis, Diane Biegel
en Limba Engleză Hardback – 4 noi 2003
Navigate the complex and multidisciplinary path of drug discovery procedures with Drug Discovery Strategies and Methods-a well-organized and timely reference that analyzes methods in target identification and validation, lead detection, compound optimization, and biological testing. This volume addresses challenges encountered during the discovery of new pharmaceutical candidates including the use of cutting-edge techniques utilized in drug design and development. It considers key elements in the drug design cycle ranging from appropriateness of targets and disease models to compound characterization, safety, and efficacy and the role of protein crystallography in structure-based drug design.
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Specificații

ISBN-13: 9780824706913
ISBN-10: 0824706919
Pagini: 348
Dimensiuni: 210 x 280 x 24 mm
Greutate: 0.61 kg
Ediția:New.
Editura: CRC Press
Colecția CRC Press
Locul publicării:Boca Raton, United States

Public țintă

Professional

Cuprins

1 Protein Crystallography in Structure based Drug Design, 2 SRS Homology-2 Domains and Structure-Based, Small Molecule Library Approaches to Drug Discovery, 3Three-Dimensional Structure of the Inhibited Catalytic Domain of Human Stromelysin-1 by Heteronuclear NMR Spectroscopy, 4 Cannabinergics: Old and New Therapeutic Possibilities, 5 Development of PET and SPECT Radioligands for Cannabinoid Receptors, 6 Structural and Pharmacological Aspects of Peptidomimetics, 7 Linkers and Resins for Solid-Phase Synthesis, 8 Allosteric Modulation of G Protein -Coupled Receptors: Implications for Drug Action 9 Protein Misfolding and Neurodegenerative Disease: Therapeutic Opportunities 10 Uncoating and Adsorption Inhibitors of Rhinovirus Replication, 11 Profiles of Prototype Antiviral Agents Interfering with the Initial Stages of HIV Infection

Notă biografică

Alexandros Makriyannis University of Connecticut, Storrs, Connecticut, U.S.A.

Descriere

This volume addresses challenges encountered during the discovery of new pharmaceutical candidates including the use of cutting-edge techniques utilized in drug design and development.