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Drug-Drug Interactions: Scientific and Regulatory Perspectives de J. Thomas August

Drug-Drug Interactions: Scientific and Regulatory Perspectives: Advances in Pharmacology, cartea 43

J. Thomas August, Ferid Murad, M. W. Anders, Joseph T. Coyle Albert Li
en Limba Engleză Hardback – 5 noi 1997
Drug–Drug Interactions is a comprehensive review of the scientific and regulatory perspectives of drug–drug interactions from the point-of-view of academia, industry, and government regulatory agencies. This book is intended for professionals in the pharmaceutical industry, health care, and governmental regulatory agencies. Topics of interest include the mechanistic understanding of drug–drug interactions, the prediction of drug–drug interaction potential of new drugs, and the avoidance of clinically significant drug–drug interaction in patients.

  • Provides useful references on the science of drug-drug interactions
  • Describes in a basic and comprehensive manner drug-drug interactions from the mechanistic viewpoint
  • Contains original data from academic and industrial laboratories
  • Presents an overview of regulatory agency positions
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Specificații

ISBN-13: 9780120329441
ISBN-10: 0120329441
Pagini: 304
Dimensiuni: 152 x 229 x 19 mm
Greutate: 0.63 kg
Editura: ELSEVIER SCIENCE
Seria Advances in Pharmacology

Public țintă

Professionals in the pharmaceutical industry, health care industry, and governmental regulatory agencies. Students and researchers in the areas of pharmacology, toxicology, pharmacokinetics, and medicine.

Cuprins

J. Collins, Foreword.A.P. Li, Preface.A.P. Li, Overview: Scientific Basis of Pharmacokinetic Drug-Drug Interactions.F.P. Guengerich, Role of Cytochrome P450 Enzymes in Drug-Drug Interactions.J.M. Sauer, E.R. Stine, L. Gunawardhana, D.A. Hill, and I.G. Sipes, The Liver as a Target for Chemical-Chemical Interactions.A.D. Rodrigues and S.L. Wong, Applications of Human Liver Microsomes in Metabolism-Based Drug-Drug Interactions.A.P. Li, Applications of Human Hepatocytes as an Experimental System for the Evaluation of Pharmacokinetic Drug-Drug Interactions.J.L. Ferrero and K. Brendal, Liver Slices as a Model in Drug Metabolism and Drug-Drug Interactions.C.L. Crespi and B.W. Penman, The Use of cDNA Expressed Human Cytochrome P450 Enzymes to Study Potential Drug-Drug Interactions.G.L. Kedderis, Pharmacokinetics of Drug Interactions.T.N. Thompson, Experimental Models for Evaluating Enzyme Induction Potential of New Drug Candidates in Animals and Man and a Strategy for Their Use.J.D. Balian, Metabolic Drug-Drug Interactions: Perspective from U.S. FDA Medical and Clinical Pharmacology Reviewers.M. Jurima-Romet, Drug Interactions: Perspectives of the Canadian Directorate.

Recenzii

Praise for the Series"Recommended not only to pharmacologists but also to all those in related disciplines." --NATURE "The works do represent an extensive compilation of recent data by outstanding researchers in this area. They are generally scientifically excellent, the bibliographies are good, and the individual reports are clear, concise, and extremely well illustrated." --H.E. Kaufmann in CHEMOTHERAPY "Superb reading material." --JOURNAL OF PHARMACEUTICAL SCIENCES "This book represents a comprehensive review of drug-drug interaction and is unique since the contributors are from all facets of the workplace, including academic institutes, government, and industry... The most attractive feature of the book is its well-focused subject area with the emphasis on the importance of P-450 enzymes in drug interactions and how government regulatory agencies evaluate them... It is unique since it presents the regulatory aspects of drug evaluations as an integral part of the science of drug-drug interactions." --Rajendar Mehta, PhD, University of Illinois at Chicago College of Medicine for DOODY'S PUBLISHING