Drug Metabolism: Current Concepts
Editat de Mino R. Caira, Corina Ionescuen Limba Engleză Hardback – 28 feb 2006
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Specificații
ISBN-13: 9781402041419
ISBN-10: 1402041411
Pagini: 436
Ilustrații: XIV, 422 p.
Dimensiuni: 155 x 235 x 22 mm
Greutate: 0.91 kg
Ediția:2005
Editura: SPRINGER NETHERLANDS
Colecția Springer
Locul publicării:Dordrecht, Netherlands
ISBN-10: 1402041411
Pagini: 436
Ilustrații: XIV, 422 p.
Dimensiuni: 155 x 235 x 22 mm
Greutate: 0.91 kg
Ediția:2005
Editura: SPRINGER NETHERLANDS
Colecția Springer
Locul publicării:Dordrecht, Netherlands
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Public țintă
ResearchCuprins
Drug Metabolism In Context: Introduction.- Absorption.- Drug Distribution.- Dynamics Of Drug Action.- Drug Clearance.- Dynamics Of Drug Clearance.- Pathways Of Biotransformation – Phase I Reactions: Introduction.- Phase I And Phase Ii Metabolism: General Considerations.- Oxidations Involving The Microsomal Mixed-Function Oxidase System.- Oxidations Involving Other Enzymatic Systems.- Metabolic Reactions Involving Reduction.- Hydrolysis.- Miscellanous Phase I Reactions.- The Fate Of Phase I Reaction Products.- . Pathways Of Biotransformation – Phase I Reactions: Introduction.- Glucuronidation.- Acetylation.- Glutathione Conjugation.- Other Conjugative Reactions.- Concluding Remarks.- Enzymatic Systems Involved In Drug Biotransformation: Ntroduction.- Interaction Between A Drug Substrate And An Enzyme.- Enzyme Systems With Specific Roles.- Final Remarks.- Induction And Inhibition Of Drug-Metabolising Enzymes.- Introduction.- Induction.- Inhibition.- Consequences Of The Above Phenomena.- Dietary And Non-Dietary Factors In Enzyme Induction And Inhibition.- Factors That Influence Drug Biotransformation.- Introduction.- Intrinsic Factors.- Environmental Factors.- Further Observations.- Impact Of Gene Variability On Drug Metabolism.- Introduction.- Basic Principles Of Pharmacogenetics.- Pharmaco-Informatics.- Implications For Third Millennium Medicine.- Drug Interactions And Adverse Reactions: Introduction.- Drug-Drug Interactions.- Interactions Between Drugs And Other Entities.- Adverse Reactions.- Summary.- Strategies For Drug Design.- Introduction.- Pharmacokinetics And Metabolism In Drug Research.- The Role Of Formulation.- Concluding Remarks.- Index
Textul de pe ultima copertă
Drug Metabolism: Current Concepts
Corina Ionescu and Mino R Caira
Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book.
The book includes chapters on
ADME (drug absorption, distribution, metabolism and elimination)
Pathways of biotransformation (Phase I and Phase II metabolic reactions)
Enzymatic systems involved in biotransformation
Induction and inhibition of drug-metabolising enzymes
Factors that influence drug biotransformation
The role of pharmacogenetics
Drug-drug interactions and adverse reactions
Strategies for drug design.
This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.
Corina Ionescu and Mino R Caira
Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book.
The book includes chapters on
ADME (drug absorption, distribution, metabolism and elimination)
Pathways of biotransformation (Phase I and Phase II metabolic reactions)
Enzymatic systems involved in biotransformation
Induction and inhibition of drug-metabolising enzymes
Factors that influence drug biotransformation
The role of pharmacogenetics
Drug-drug interactions and adverse reactions
Strategies for drug design.
This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.
Caracteristici
Includes an extensive tabulation of drug-drug interactions and a section dealing with the relatively new topic of pharmacogenetics, as it relates to drug metabolism. Emphasises the importance of metabolism throughout the lifetime of the drug development process, bringing together chemical design and optimisation with eventual clinical use. Includes many more types of metabolic reactions and interactions than existing publications. An emphasis on the understanding of the topics at the molecular level. Avoids details of chemical methodology, allowing the reader to focus on the concepts underlying drug delivery optimisation through a knowledge of the principles of biotransformation. Provides a new, detailed and accessible presentation of drug-drug interactions and adverse reactions at the molecular level. Systematically outlines modern strategies in drug design based primarily on metabolic considerations. The treatment of drug design is more comprehensive than previous coverage as it covers all aspects and implications of drug metabolism the authors consider relevant to the target