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Drug Metabolism: Chemical and Enzymatic Aspects

Autor Jack P. Uetrecht, William Trager
en Limba Engleză Paperback – 18 dec 2020
In order to understand drug metabolism at its most fundamental level, pharmaceutical scientists must be able to analyze drug compound structure and predict possible metabolic pathways in order to avoid the risk of adverse reactions that lead to the withdrawal of a drug from the market. This title is a comprehensive guide for recognizing the chemical underpinnings of drug metabolism. While there are numerous resources available to medicinal chemists for understanding drug structure, and to pharmacologists for discerning drug metabolism from a biological standpoint, no resource currently exists that links the chemical and biological aspects in language accessible to both-making it challenging for both groups to fully comprehend how a drug is metabolized, as well as the potential effects of the metabolites. Drug Metabolism: Chemical and Enzymatic Aspects provides extensive material to help understand drug metabolism within a biological context, and for predicting and mitigating adverse drug reactions.
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Specificații

ISBN-13: 9780367453022
ISBN-10: 0367453029
Pagini: 179
Dimensiuni: 178 x 254 mm
Greutate: 0.45 kg
Ediția:1
Editura: CRC Press
Colecția CRC Press

Public țintă

Academic and Professional Practice & Development

Cuprins

Background for Non-Chemists. Background for Chemists. Oxidation Pathways and the Enzymes That Mediate Them. Reductive Pathways. Hydolytic Pathways. Conjugation Pathways. Reactive Metabolites

Notă biografică

Uetrecht, Jack P. | Trager, William

Descriere

In order to understand drug metabolism at its most fundamental level, pharmaceutical scientists must be able to analyze drug compound structure and predict possible metabolic pathways in order to avoid the risk of adverse reactions that lead to the withdrawal of a drug from the market. This title is a comprehensive guide for recognizing the chemic