Drug Resistance in Leishmania Parasites: Consequences, Molecular Mechanisms and Possible Treatments
Editat de Alicia Ponte-Sucre, Emilia Diaz, Maritza Padrón-Nievesen Limba Engleză Paperback – 14 oct 2014
| Toate formatele și edițiile | Preț | Express |
|---|---|---|
| Paperback (1) | 1370.47 lei 38-44 zile | |
| SPRINGER VIENNA – 14 oct 2014 | 1370.47 lei 38-44 zile | |
| Hardback (1) | 1096.78 lei 6-8 săpt. | |
| SPRINGER VIENNA – 4 sep 2012 | 1096.78 lei 6-8 săpt. |
Preț: 1370.47 lei
Preț vechi: 1442.60 lei
-5% Nou
Puncte Express: 2056
Preț estimativ în valută:
262.31€ • 275.19$ • 217.60£
262.31€ • 275.19$ • 217.60£
Carte tipărită la comandă
Livrare economică 25-31 ianuarie 25
Preluare comenzi: 021 569.72.76
Specificații
ISBN-13: 9783709117064
ISBN-10: 3709117062
Pagini: 476
Dimensiuni: 155 x 235 x 25 mm
Greutate: 0.66 kg
Ediția:2013
Editura: SPRINGER VIENNA
Colecția Springer
Locul publicării:Vienna, Austria
ISBN-10: 3709117062
Pagini: 476
Dimensiuni: 155 x 235 x 25 mm
Greutate: 0.66 kg
Ediția:2013
Editura: SPRINGER VIENNA
Colecția Springer
Locul publicării:Vienna, Austria
V-ar putea interesa
-
The Economics of Infectious DiseaseJennifer A. Roberts-45%Preț: 359.73 lei655.70 lei -
Rapid Medical Countermeasure Response to Infectious Diseases: Enabling Sustainable Capabilities Through Ongoing Public- And Private-Sector PartnershipForum on Medical and Public Health Prepa-5%Preț: 261.90 lei275.69 lei -
-5%Preț: 130.91 lei137.80 lei -
Oral MicrobiologyPhilip D. Marsh-5%Preț: 384.73 lei404.97 lei -
Paralysed with Fear: The Story of PolioGareth WilliamsPreț: 483.19 lei -
-5%Preț: 279.38 lei294.08 lei -
-14%Preț: 1040.41 lei1214.36 lei -
Handbook of Meningococcal Disease ManagementIan Feavers-5%Preț: 319.52 lei336.34 lei -
Infections in HematologyGeorg Maschmeyer-5%Preț: 710.77 lei748.18 lei
Public țintă
ResearchCuprins
Foreword.-
Introduction.
Leishmaniasis,
the
biology
of
a
parasite.Alicia
Ponte
Sucre.-
I
Determinant
features
in
leishmaniasis.-
1
Molecular
evolution
and
phylogeny
of
Leishmania.Gabriele
Schoenian,Elisa
Cupolillo,
Isabel
Mauricio.-
2
The
role
of
reservoirs:
Canine
leishmaniasis.Lenea
Campino,
Carla
Maia.-
3
Epidemiology
of
leishmaniasis
in
the
time
of
drug
resistance.Jean
Claude
Dujardin,
Saskya
Decuypere.-
IILeishmaniaand
the
immune
system.-
4
The
role
of
the
immune
system
in
resistance
to
infection.Lukasz
Kedzierski,
Krystal
J.
Evans.-
5
Vaccination
as
a
control
measure.Katrin
Färber
,
Heidrun
Moll.-6
Leishmania
vaccines:
Past,
Present
and
Future.Bhavana
SethuLakshmi,RentalaMadhubala.-III
Challenges
in
the
diagnosis,
treatment
and
control
of
leishmaniasis
in
times
of
drug
resistance.-
7
Co-infection
with
HIV.Margriet
den
Boer,
Luis
Rivas,
Jorge
Alvar.-8
Visceral
leishmaniasis.Shyam
Sundar,J
aya
Chakravarty.-
9
American
Tegumentary
leishmaniasis.Olga
Zerpa,
Alicia
Ponte-Sucre.-
IV
Molecular
features
of
drug-resistantLeishmania.-
10
Genetic
expression
and
drug
resistance,
the
role
of
proteomics.Patricia
Cuervo,
Jose
Batista
de
Jesus.-11
The
role
of
ABC
transporters
in
drug-resistantLeishmania.
Adriano
C
Coelho,Paulo
C
Cotrim.-12
Functional
analysis
ofLeishmaniamembrane
(non
ABC)
transporters
involved
in
drug
resistance.Scott
M
Landfear.-
13
Intracellular
mechanisms
of
resistance
inLeishmania.-V
Pharmacology
and
chemotherapy
of
leishmaniasis.Mitali
Chatterjee.-
14
Classical
vs
new
Treatment
regimens.Louis
Maes,
Raquel
Andreia
Inocencio
da
Luz,
Paul
Cos,
Vanessa
Yardley.-
15
Drug
targets,
drug
effectors
and
drug
targeting
and
delivery.Philippe
M
Loiseau,
Gillian
Barratt.-
16
Mechanisms
of
miltefosine
resistance
inLeishmania.
Francisco
Gamarro,María
P
Sánchez-Cañete,
Santiago
Castanys.-17
P-glycoprotein-like
transporters
inLeishmania:
a
search
for
reversal
agents.Bruno
Pradines.-
VI
Strategies
to
circumvent
drug
resistance
inLeishmania.-18
The
relevance
of
susceptibility
tests,
breakpoints
and
markers.Louis
Maes,
Paul
Cos
and
Simon
Croft.-
19
The
Concept
of
Fitness
and
drug
resistance
inLeishmania.
Alicia
Ponte-Sucre,
Emilia
Diaz,
Maritza
Padrón-Nieves.-
Notă biografică
Professor
Dr.
Emilia
Diaz
Emilia Diaz studied Pharmacy at the Central University of Venezuela (UCV) in Caracas and became Doctor of Sciences in Pharmacology in 2003 in the same university. From 1999 to 2003 she was Assistant Professor at the Chair of Biology, Faculty of Pharmacy, UCV. Currently she is Aggregate Professor of Human Physiology, Faculty of Medicine, UCV. Initially her research interests were related to the comprehension of the mechanisms involved in the diuretic and natriuretic action of adrenomedullin, and the role of the dopaminergic system in the adrenomedullin-induced diuresis and natriuresis. Recently her research interests are focused towards the comprehension of the mechanisms involved in proficiency and fitness in drug resistantLeishmaniaand in the initial interaction events (chemotaxis) occurring betweenLeishmaniaand its host cell.
Professor Dr. Maritza Padrón Nieves
Maritza Padrón Nieves studied Biology at UCV in Caracas and became Magister Scientiarum in Pharmacology in 1993 and Doctor of Sciences in Pharmacology in 2011 in the same university. From 1994 to 2000 she was head of the Department of Basic Sciences at the School of Nursery, UCV. Currently she is Aggregate Professor and head of the Human Pharmacology and Toxicology Chair, Faculty of Medicine, UCV. Initially her research interests were related to the comprehension of the mechanisms involved in digoxin intoxication. Recently she has dedicated her scientific interest to the identification and characterization of molecular markers of resistance in theLeishmaniasp. infection model.
Professor Dr. Alicia Ponte-Sucre
Alicia Ponte-Sucre studied Education in Biological Sciences at the Andrés Bello Catholic University in Caracas and became Magister Scientiarum in Physiology and Biophysics in 1981 at the Venezuelan Institute of Scientific Research and Doctor of Sciences in Pharmacology in 1993 at the UCV. She spent a year (1999-2000) at the University of Würzburg with a scholarship from the Alexander von Humboldt Foundation and was a staff scientist (2003-2007) at the same university, within a multidisciplinary project from the German Research Council. Currently she is Full Professor in Human Physiology and Coordinator for Scientific Affairs of the Faculty of Medicine, UCV. Initially, her studies were focused on the physical-chemical behavior of black lipid membranes. Later, her scientific activity was oriented towards the characterization of receptors involved in air-way smooth muscle contraction. Recently her interests have been focused towards the study of parasite metabolism and membrane transporters essential for parasite survival and involved in drug resistance, and the mechanisms involved in cellular differentiation and parasite-host interaction in theLeishmaniamodel. Additionally she has characterized natural products and target oriented designed compounds as potential therapeutic agents.
Emilia Diaz studied Pharmacy at the Central University of Venezuela (UCV) in Caracas and became Doctor of Sciences in Pharmacology in 2003 in the same university. From 1999 to 2003 she was Assistant Professor at the Chair of Biology, Faculty of Pharmacy, UCV. Currently she is Aggregate Professor of Human Physiology, Faculty of Medicine, UCV. Initially her research interests were related to the comprehension of the mechanisms involved in the diuretic and natriuretic action of adrenomedullin, and the role of the dopaminergic system in the adrenomedullin-induced diuresis and natriuresis. Recently her research interests are focused towards the comprehension of the mechanisms involved in proficiency and fitness in drug resistantLeishmaniaand in the initial interaction events (chemotaxis) occurring betweenLeishmaniaand its host cell.
Professor Dr. Maritza Padrón Nieves
Maritza Padrón Nieves studied Biology at UCV in Caracas and became Magister Scientiarum in Pharmacology in 1993 and Doctor of Sciences in Pharmacology in 2011 in the same university. From 1994 to 2000 she was head of the Department of Basic Sciences at the School of Nursery, UCV. Currently she is Aggregate Professor and head of the Human Pharmacology and Toxicology Chair, Faculty of Medicine, UCV. Initially her research interests were related to the comprehension of the mechanisms involved in digoxin intoxication. Recently she has dedicated her scientific interest to the identification and characterization of molecular markers of resistance in theLeishmaniasp. infection model.
Professor Dr. Alicia Ponte-Sucre
Alicia Ponte-Sucre studied Education in Biological Sciences at the Andrés Bello Catholic University in Caracas and became Magister Scientiarum in Physiology and Biophysics in 1981 at the Venezuelan Institute of Scientific Research and Doctor of Sciences in Pharmacology in 1993 at the UCV. She spent a year (1999-2000) at the University of Würzburg with a scholarship from the Alexander von Humboldt Foundation and was a staff scientist (2003-2007) at the same university, within a multidisciplinary project from the German Research Council. Currently she is Full Professor in Human Physiology and Coordinator for Scientific Affairs of the Faculty of Medicine, UCV. Initially, her studies were focused on the physical-chemical behavior of black lipid membranes. Later, her scientific activity was oriented towards the characterization of receptors involved in air-way smooth muscle contraction. Recently her interests have been focused towards the study of parasite metabolism and membrane transporters essential for parasite survival and involved in drug resistance, and the mechanisms involved in cellular differentiation and parasite-host interaction in theLeishmaniamodel. Additionally she has characterized natural products and target oriented designed compounds as potential therapeutic agents.
Caracteristici
Most
recent
and
comprehensive
book
about
Leishmania
and
Leishmaniasis
A useful and copious guide for clinicians and researchers alike, working in the area of infectious disease and vaccine development.
Describes epidemiology, pathology and molecular features of Leishmaniasis and drug resistance
Edited and written by experts in the field. Discusses ideas for novel therapies
A useful and copious guide for clinicians and researchers alike, working in the area of infectious disease and vaccine development.
Describes epidemiology, pathology and molecular features of Leishmaniasis and drug resistance
Edited and written by experts in the field. Discusses ideas for novel therapies
Textul de pe ultima copertă
One of the main problems concerning therapeutic tools for the treatment of parasitic diseases, including leishmaniasis, is that some field parasites are naturally resistant to the classical drugs; additionally, current therapies may select parasites prone to be resistant to the applied drugs. These features are (at least partially) responsible for the disappointing persistence of the disease and resultant deaths worldwide. This book provides a comprehensive view of the pathology of the disease itself, and of parasitic drug resistance, its molecular basis, consequences and possible treatments. Scientists both from academic fields and from the industry involved in biomedical research and drug design, will find in this book a valuable and fundamental guide that conveys the knowledge needed to understand and to improve the success in combating this disease worldwide.