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Enantiomer Separation: Fundamentals and Practical Methods

Editat de Fumio Toda
en Limba Engleză Hardback – 27 ian 2005
In spite of important advances in asymmetric synthesis, chiral compounds cannot all be obtained in a pure state by asymmetric synthesis. As a result, enantiomer separation remains an important technique for obtaining optically active materials. Although asymmetric synthesis is a once-only procedure, an enantiomer separation process can be repeated until the optically pure sample is obtained. This book discusses several new enantiomer separation methods using modern techniques developed by experts in the field. These methods consist mainly of the following three types: 1) Enantiomer separation by inclusion complexation with a chiral host compound 2) Enantiomer separation using biological methods 3) Enantiomer separation by HPLC chromatography using a column containing a chiral stationary phase. Separation of a racemic compound has been called “optical resolution” or simply “resolution”. Nowadays, the descriptions “enantiomer resolution” or “enantiomer separation” are also commonly used. Accordingly, “Enantiomer Separation” is used in the title of this book. The editor and all chapter contributors hope that this book is helpful for scientists and engineers working in this field.
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Specificații

ISBN-13: 9781402023361
ISBN-10: 1402023367
Pagini: 333
Ilustrații: VII, 333 p.
Dimensiuni: 210 x 297 x 18 mm
Greutate: 0.74 kg
Ediția:2004
Editura: SPRINGER NETHERLANDS
Colecția Springer
Locul publicării:Dordrecht, Netherlands

Public țintă

Research

Cuprins

Optical resolutions by inclusion complexation with a chiral host compound.- Crystalline dipeptides: their molecular recognition to be useful to enantiomer separation.- Optical resolution via complex formation with O,O'-dibenzoyltataric acid.- Spontaneous chiral crystallization of achiral materials and absolute asymmetric transformation in the chiral crystalline environment.- Preferential enrichment: a dynamic enantiomeric resolution phenomenon caused by polymorphic transition during crystallization.- Optical resolution by means of crystallization.- Lipase-catalyzed kinetic resolution of racemates: a versatile method for the separation of enantiomers.- Enzymatic kinetic resolution.- Preparative-scale separation of enantiomers on chiral stationary phases by gas chromatography.- Practical resolution of enantiomers by high-performance liquid chromatography.

Recenzii

From the reviews:
"This is an authoritative account of … the methods applicable to the large-scale separation of enantiomers, edited by a leading authority on inclusion complexation using crystalline chiral host molecules … . the basic science of enantiomer separation is well documented. The text is clearly printed … . this book does provide accurate and detailed information on recently emerging techniques, and should be very useful to development chemists and scale-up scientists requiring access to single enantiomers on the multi-gram scale." (D. R. Taylor, Chromatographia, Vol. 63 (5-6), 2006)
"This book covers enantiomer separation, with an emphasis on separation by chiral inclusion complexes and crystallization, biological methods … as well as preparative liquid and gas chromatographic methods. … this book succeeds in covering the practical methods for separating enantiomers on a preparative scale. … it can be recommended as a resource for those working in the field of enantiomer separation, especially enzymatic resolutions, the practical aspects of crystallization, and preparative scale chromatography techniques." (Thomas K. Green, Journal of the American Chemical society, Vol. 128 (5), 2006)

Caracteristici

This book is a new edition written by several experts working in the field of modern enantiomer separation chemistry. This edition is completely different from those edited previously from the viewpoint of classical enantiomer separation methods This book contains modern practical methods of enantiomer separation.