Type-2 Diabetes is now a severe health problem worldwide. Patients with this disease have 2-4 times greater risk of renal and cardiovascular complications, mortality and morbidity. This unique book includes topics like pathophysiology and complications. Comprehending the etiology of the onset and advancement of this disease is crucial to avoid its complications and delay the progress. The pathophysiology includes a number of mechanisms and aspects from the micro (molecular) to the macro (neuro-hormonal mechanisms and beta-cell function in the pancreas). This book contains topics like sympathetic nervous system imbalance, renal complexities, atherosclerosis, and foot ulcers which are mostly seen in diabetic patients. The aim of this book is to provide the readers with helpful knowledge regarding the field and assist clinicians and researchers.