Epigenetics and Proteomics of Leukemia: A Synergy of Experimental Biology and Computational Informatics
Autor R¯uta Navakauskien˙e, Dalius Navakauskas, Veronika Borutinskait˙e, Dalius Matuzevi˘ciusen Limba Engleză Paperback – 15 sep 2022
Epigenetics and Proteomics of Leukemia is an ideal book for advanced biomedical scientists and students, medical doctors and students, bioinformatics and health informatics researchers, computational biologists, structural biologists, systems biologists, and bioengineers.
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Specificații
ISBN-13: 9783030687106
ISBN-10: 3030687104
Pagini: 406
Ilustrații: LIX, 406 p. 156 illus., 107 illus. in color.
Dimensiuni: 155 x 235 mm
Greutate: 0.65 kg
Ediția:1st ed. 2021
Editura: Springer International Publishing
Colecția Springer
Locul publicării:Cham, Switzerland
ISBN-10: 3030687104
Pagini: 406
Ilustrații: LIX, 406 p. 156 illus., 107 illus. in color.
Dimensiuni: 155 x 235 mm
Greutate: 0.65 kg
Ediția:1st ed. 2021
Editura: Springer International Publishing
Colecția Springer
Locul publicării:Cham, Switzerland
Cuprins
Overview / Introduction
Section I: Epigenetics in Leukemia
Chapter 1: Genetic and Epigenetic Alterations in Leukemia
Chapter 2: Epigenetic Modifiers and Their Inhibitors in Leukemia Treatment
Chapter 3: Chromatin Remodeling during Leukemia Cell Proliferation and Differentiation
DNA Methylation and Epigenetic Regulation
Chromatin Functional Regulation by Histone Modification
Chapter 4: Approaches to Epigenetic Treatment of Leukemia
Section II: Proteomics in Leukemia
Chapter 5: Proteome in Leukemic vs. Differentiated Leukemia Cells
Chapter 6: Protein Phosphorylation in Leukemia
Chapter 7: Computational Methods for Proteome Analysis
2DE Fractionation and Visualization
Proteomic Data Processing
Proteomic Data Analysis
Image Acquisition and Data Analysis
Section III: Protein Localization in Leukemia
Chapter 8: Protein Translocation into the Nucleus during Leukemia Cell Differentiation
Chapter 9: Protein Visualization in Leukemic Cells
Chapter 10: Computational Methods for Protein Localization Estimation
Fluorescent Image Processing
Fluorescent Image Acquisition and Analysis
Section IV: Future Therapy in Leukemia
Notă biografică
Rūta NAVAKAUSKIENĖ, Dr. Prof.
Department of Molecular Cell Biology, Institute of Biochemistry, Life Sciences Center, Vilnius University, Sauletekio av. 7, LT-10257 Vilnius, Lithuania
Dalius NAVAKAUSKAS, Dr. Prof.
Department of Electronic Systems, Faculty of Electronics, Vilnius Gediminas Technical University, Naugarduko st. 41-426, LT-03227 Vilnius, Lithuania
Veronika BORUTINSKAITĖ, Dr.
Department of Molecular Cell Biology, Institute of Biochemistry, Life Sciences Center, Vilnius University, Sauletekio av. 7, LT-10257 Vilnius, Lithuania
Dalius MATUZEVIČIUS, Dr. Assoc. Prof.
Department of Electronic Systems, Faculty of Electronics, Vilnius Gediminas Technical University, Naugarduko st. 41-413, LT-03227 Vilnius, Lithuania
Textul de pe ultima copertă
This book reviews the current state of epigenetics and proteomics of leukemia and introduces the methods that are important to process and evaluate these factors in leukemia. In particular, epigenetic modifiers and their inhibitors in leukemia treatment as well as approaches to the epigenetic treatment of leukemia are covered. Various computational methods for proteome analysis are also described in detail, including 2DE fractionation and visualization, proteomic data processing, image acquisition and data anlaysis, and more. Protein localization in leukemia is also covered, in addition to the future of leukemia therapy.
Epigenetics and Proteomics of Leukemia is an ideal book for advanced biomedical scientists and students, medical doctors and students, bioinformatics and health informatics researchers, computational biologists, structural biologists, systems biologists, and bioengineers.
Epigenetics and Proteomics of Leukemia is an ideal book for advanced biomedical scientists and students, medical doctors and students, bioinformatics and health informatics researchers, computational biologists, structural biologists, systems biologists, and bioengineers.
Caracteristici
Compiles the latest research on the study of epigenetics and proteomics of leukemia
Introduces computational methods to evaluate and analyze changes in proteome and chromatin remodeling
Demonstrates synergy of biological methods with computational informatics for leukemia research
Introduces computational methods to evaluate and analyze changes in proteome and chromatin remodeling
Demonstrates synergy of biological methods with computational informatics for leukemia research