Erythropoietin and the Nervous System
Editat de Ahmet Hökeen Limba Engleză Paperback – 18 noi 2014
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Specificații
ISBN-13: 9781489973832
ISBN-10: 1489973834
Pagini: 236
Ilustrații: XI, 223 p.
Dimensiuni: 155 x 235 x 12 mm
Greutate: 0.34 kg
Ediția:2006
Editura: Springer Us
Colecția Springer
Locul publicării:New York, NY, United States
ISBN-10: 1489973834
Pagini: 236
Ilustrații: XI, 223 p.
Dimensiuni: 155 x 235 x 12 mm
Greutate: 0.34 kg
Ediția:2006
Editura: Springer Us
Colecția Springer
Locul publicării:New York, NY, United States
Public țintă
ResearchDescriere
Erythropoietin (EPO) is a chemokine hormone that is widely distributed throughout the body. In addition to its traditional role as a hormone that stimulates red blood cell production, in recent years many laboratories have shown that EPO can act as a neuroprotective compound in a variety of injury paradigms in the nervous system. Past experience with relatively safety profile of this FDA-approved drug makes it an ideal candidate to take it into clinical trials for neuroprotection. We are on the verge of major clinical trials using this drug for neuroprotection in diseases ranging from stroke, to transverse myelitis to chemotherapy-induced peripheral neuropathy. This is the first book of its kind that brings together researchers from many different disciplines of neuroscience to review the current state-of-the-art in EPO and the nervous system. This book will benefit scientists and clinicians interested in neuroprotection in the broadest sense.
Cuprins
History and Biology of Erythropoietin in Hematopoietic and Non-Neural Tissues.- Expression of Erythropoietin and Its Receptor in the Central Nervous System.- Erythropoietin and Neuroprotection in the Central Nervous System: Intracellular Signaling Pathways.- Regulation of Erythropoietin Expression in the Nervous System: The Hypoxia Inducible Factor.- Erythropoietin Neuroprotection in the Term and Preterm Infant: Safety and Efficacy.- Erythropoietin for the Treatment of Acute Ischemic Stroke: Preclinical Rationale.- Erythropoietin Neuroprotection in the Retina.- Erythropoietin for Treatment of Human Brain Disease: Experience from Proof-of-Concept Trials.- Erythropoietin in Spinal Cord Injury.- Erythropoietin and Neuroprotection in the Peripheral Nervous System: In Vivo Studies.- An Endogenous Pathway Preventing Axonal Degeneration Mediated by Schwann Cell — Derived Erythropoietin.- Role of Erythropoietin in Inflammatory Pathologies of the CNS.- Development of Non-Erythropoietic Erythropoietin Variants for Neuroprotection.
Textul de pe ultima copertă
Erythropoietin and the Nervous System is the first book of its kind to bring together researchers from many different disciplines of neuroscience to present a current state-of-the-art review of multiple aspects of erythropoietin research as it relates to the nervous system. Erythropoietin (EPO) is a chemokine hormone that is widely distributed throughout the body. In addition to its traditional role as a hormone that stimulates red blood cell production, in recent years many laboratories have shown that EPO can act as a neuroprotective compound in a variety of injury paradigms in the nervous system. Past experience with the relatively safety profile of this FDA-approved drug makes it an ideal candidate to take into clinical trials for neuroprotection. We are on the verge of major clinical trials using this drug for neuroprotection in diseases ranging from stroke, to transverse myelitis to chemotherapy-induced peripheral neuropathy.
This book should stimulate new research on erythropoietin and the nervous system and bring new investigators to the field. It will benefit scientists and clinicians interested in neuroprotection in the broadest sense.
This book should stimulate new research on erythropoietin and the nervous system and bring new investigators to the field. It will benefit scientists and clinicians interested in neuroprotection in the broadest sense.
Caracteristici
The first book of its kind that brings together researchers from many different disciplines of neuroscience together to review the current state-of-the-art in EPO and the nervous system
Includes supplementary material: sn.pub/extras
Includes supplementary material: sn.pub/extras