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Essential Concepts in Molecular Pathology de William B. Coleman

Essential Concepts in Molecular Pathology

Editat de William B. Coleman, Gregory J. Tsongalis
en Limba Engleză Paperback – 25 noi 2019
Essential Concepts in Molecular Pathology, Second Edition, offers an introduction to molecular genetics and the "molecular" aspects of human disease. The book illustrates how pathologists harness their understanding of these entities to develop new diagnostics and treatments for various human diseases. This new edition offers pathology, genetics residents, and molecular pathology fellows an advanced understanding of the molecular mechanisms of disease that goes beyond what they learned in medical and graduate school.
By bridging molecular concepts of pathogenesis to the clinical expression of disease in cell, tissue and organ, this fully updated, introductory reference provides the background necessary for an understanding of today’s advances in pathology and medicine.


  • Explains the practice of "molecular medicine" and the translational aspects of molecular pathology, including molecular diagnostics, molecular assessment and personalized medicine
  • Orients non-pathologists on what pathologists look for and how they interpret their observational findings based on histopathology
  • Provides the reader with what is missing from most targeted introductions to pathology—the cell biology behind pathophysiology
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Specificații

ISBN-13: 9780128132579
ISBN-10: 0128132574
Pagini: 634
Dimensiuni: 216 x 276 x 34 mm
Ediția:2
Editura: ELSEVIER SCIENCE

Public țintă

Biomedical graduate students, allied health students, medical students studying pathology, human disease, and the translational aspects of basic science; residents and postdoctoral fellows in pathology, laboratory medicine, and internal medicine; practicing basic scientists and physician scientists.

Cuprins

PART I Essential Pathology - Mechanisms of Disease 1. Molecular Mechanisms of Cell Death 2. Acute and Chronic Inflammation 3. Infection and Host Response 4. Neoplasia
PART II Concepts in Molecular Biology and Genetics 5. Basic Concepts in Human Molecular Genetics 6. The Human Genome: Implications for the Understanding of Human Disease 7. The Human Transcriptome: Implications for the Understanding of Human Disease 8. The Human Epigenome: Implications for the Understanding of Human Disease 9. Clinical Proteomics and Molecular Pathology 10. Integrative Systems Biology: Implications for the Understanding of Human Disease 11. Pathology: The Clinical Description of Human Disease 12. Molecular Pathogenesis: The Biological Basis of Human Disease and Implications for Improved Treatment of Human Disease 13. Integration of Molecular and Cellular Pathogenesis
PART IV Molecular Pathology of Human Disease 14. Molecular Basis of Cardiovascular Disease 15. Molecular Basis of Hemostatic and Thrombotic Diseases 16. Molecular Basis of Lymphoid and Myeloid Diseases 17. Molecular Basis of Diseases of Immunity 18. Molecular Basis of Pulmonary Disease 19. Molecular Basis of Diseases of the Gastrointestinal Tract 20. Molecular Basis of Liver Disease 21. Molecular Basis of Diseases of the Exocrine Pancreas 22. Molecular Basis of Diseases of the Endocrine System 23. Molecular Basis of Gynecologic Diseases 24. Molecular Pathogenesis of Kidney Diseases 25. Molecular Pathogenesis of Prostate Cancer: Somatic, Epigenetic, and Genetic Alterations 26. Molecular Biology of Breast Cancer 27. Molecular Basis of Skin Disease 28. Molecular Pathology: Neuropathology
PART V Practice of Molecular Medicine 29. Molecular Diagnosis of Human Disease 30. Molecular Assessment of Human Disease in the Clinical Laboratory 31. Pharmacogenomics and Personalized Medicine in the Treatment of Human Disease

Recenzii

"This is a well-illustrated, easy-to-read book perfectly geared toward aspiring and practicing pathologists. With the growing use of high throughput technologies by medical laboratories, clinicians increasingly rely on genomic, epigenomic, transcriptomic, and proteomic data to classify disease, predict patient outcomes, select therapy, and monitor response to treatment. This book illustrates how scientific discoveries have improved our understanding of disease and catalyzed the era of molecular-guided precision medicine. By highlighting landmark collaborative efforts like the Human Genome Project and new technologies on the horizon, it offers both historical and future-oriented perspectives on the rapidly growing field of genomic medicine. Overall, I would highly recommend this comprehensive textbook to those interested in molecular pathology." --Doody Reviews
Praise for the first edition: "The book is compact, easy to follow, filled with useful tables and figures and deserves reading by students and professionals interested in the molecular basis of disease." --Howard Reisner PhD, Professor of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, North Carolina, USA
"Finally, a book that captures the real world environment of molecular diagnosis and pathology…is available in Essential Concepts in Molecular Pathology! --Rodney E. Rohde, MS, SV, SM, MP (ASCP), Associate Professor, Texas State University-San Marcos, Clinical Laboratory Science, San Marcos, TX, USA