Evolutionary Systems Biology
Editat de Orkun S. Soyeren Limba Engleză Paperback – 9 aug 2014
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Specificații
ISBN-13: 9781489999030
ISBN-10: 1489999035
Pagini: 468
Dimensiuni: 155 x 235 x 25 mm
Greutate: 0.65 kg
Ediția:2012
Editura: Springer
Colecția Springer
Locul publicării:New York, NY, United States
ISBN-10: 1489999035
Pagini: 468
Dimensiuni: 155 x 235 x 25 mm
Greutate: 0.65 kg
Ediția:2012
Editura: Springer
Colecția Springer
Locul publicării:New York, NY, United States
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Public țintă
ResearchCuprins
Preface.-
Evolutionary
Systems
Biology:
Historical
and
Philosophical
Persepctives
on
an
Emerging
Synthesis.-
Metabolic
Networks
and
their
Evolution.-
Organization
Principles
and
their
Evolution.-
Organization
principles
in
genetic
interaction
networks.-
Evolution
of
regulatory
networks:
Nematode
vulva
induction
as
an
example
of
developmental
systems
drift.-
Life’s
attractors
understanding
developmental
systems
through
reverse
engineering
and
in
silico
evolution.-
Evolutionary
characteristics
of
bacterial
two-component
systems.-
Comparative
interaction
networks
-
bridging
genotype
to
phenotype.-
Evolution
in
silico:
from
network
structure
to
bifurcation
theory.-
On
the
search
for
design
principles
in
biological
systems.-
Towards
a
theory
of
multilevel
evolution;
long
term
information
integration
shapes
the
mutational
landscape
and
enhances
evolvability.-
Evolutionary
principles
underlying
structure
and
response
dynamics
of
cellular
networks.-
Phenotypic
plasticity
and
robustness:
Evolutionary
stability
theory,
gene
expression
dynamics
model,
and
laboratory
experiments.-
Genetic
redundancies
and
their
evolutionary
maintenance.-
Evolution
of
resource
and
energy
management
in
biologically
realistic
gene
regulatory
network
models.-
Reverse
ecology:
From
systems
to
environments
and
back.-
Bacteria-virus
coevolution.-
The
genotype-phenotype
maps
of
systems
biology
and
quantitative
genetics:
distinct
and
complementary.-
How
evolutionary
systems
biology
will
help
understand
adaptive
landscapes
and
distributions
of
mutational
effects.-
Building
synthetic
systems
to
learn
Nature’s
design
principles.-
The
robustness
continuum.-
Index.
Textul de pe ultima copertă
The
book
aims
to
introduce
the
reader
to
the
emerging
field
of
Evolutionary
Systems
Biology,
which
approaches
classical
systems
biology
questions
within
an
evolutionary
framework.
An
evolutionary
approach
might
allow
understanding
the
significance
of
observed
diversity,
uncover
“evolutionary
design
principles”
and
extend
predictions
made
in
model
organisms
to
others.
In
addition,
evolutionary
systems
biology
can
generate
new
insights
into
the
adaptive
landscape
by
combining
molecular
systems
biology
models
and
evolutionary
simulations.
This
insight
can
enable
the
development
of
more
detailed
mechanistic
evolutionary
hypotheses.
Caracteristici
Highlights
the
diverse
array
of
methodologies
and
approaches
employed
in
evolutionary
systems
biology
This book tries to decipher “evolutionary design principles” and the origins of systems level properties in biology, such as modularity, robustness, and network connectivity
Includes comparative (genomics) analyses that aim to decipher diversity in specific molecular systems
This book tries to decipher “evolutionary design principles” and the origins of systems level properties in biology, such as modularity, robustness, and network connectivity
Includes comparative (genomics) analyses that aim to decipher diversity in specific molecular systems