Fertility Preservation de Jacques Donnez

Fertility Preservation: Principles and Practice

Jacques Donnez

S. Samuel Kim

This new edition provides a much-needed reference book to accommodate emerging and expanding knowledge in fertility preservation, the rapidly growing field of reproductive medicine associated with advances in oncology. Written by a team of world-leading experts in the field and comprehensive in its scope, the book covers the full range of techniques and scientific concepts in detail. It opens with an introduction to fertility preservation in both cancer and non-cancer patients, followed by fertility preservation strategies in males and females, including medical/surgical procedures, ART, cryopreservation and transplantation of ovarian tissue, and in-vitro follicle culture. Concluding chapters address new technologies, as well as ethical, legal and religious issues. The book has been thoroughly updated, includes additional contributors, and now provides greater focus on practical and clinically relevant issues. Richly illustrated throughout, this is a key resource for clinicians specializing in reproductive medicine, gynecology, oncology, hematology, endocrinology and infertility.

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Section 1 Introduction: 1. The evolution of the assisted reproduction technologies; 2. The effect of chemotherapy on the human reproductive system; 3. The effect of radiotherapy on the human reproductive system; 4. The need for fertility preservation in cancer patients; Section 2 Reproductive biology and cryobiology: 5. Life and death in the germ line: apoptosis and the origins of DNA damage in human spermatozooa; 6. Principles of vitrification as a method of cryopreservation in reproductive biology and medicine; Section 3 Fertility preservation in cancer and non-cancer patients: 7. Fertility preservation in non-cancer patients; 8. Fertility preservation in women with ovarian endometrioma: from surgery to oocyte and ovarian tissue freezing; 9. Pediatric cancer therapy and fertility; 10. Breast cancer therapy and fertility; 11. Fertility preservation in young adults with gastrointestinal and hematological malignancies; Section 4 Fertility preservation strategies in the male: 12. Transplantation of cryopreserved spermatogonia; 13. Cryopreservation and grafting of immature testicular tissue; 14. Use of cryopreserved sperm and ART after chemotherapy or radiotherapy; Section 5 Fertility preservation strategies in the female: medical/surgical: 15. Use of GnRH analogs for prevention of chemotherapy-induced gonadotoxicity; 16. Ovarian transposition before radiotherapy Yaron Gill and Togas Tulandi; 17. Fertility-saving surgery for gynaecological cancers; 18. Results of conservative management of ovarian malignant tumours; Section 6 Fertility preservation strategies in the female: ART: 19. Embryo cryopreservation as a fertility preservation strategy; 20. Vitrification of human oocytes as a fertility preservation strategy; 21. Autotransplantation of cryopreserved ovarian tissue: techniques and results; 22. ART and oocyte donation in cancer survivors; Section 7 Ovarian cryopreservation and transplantation: 23. Ovarian cryopreservation and transplantation: overview; 24. Cryopreservation of ovarian tissue by vitrification: techniques and results; 25. Ovarian tissue cryopreservation; 26. Risk of transplanting malignant cells in cryopreserved ovarian tissue; 27. Whole ovary freezing and transplantation; Section 8 In-vitro follicle culture: 28. Molecular and cellular integrity of cultured follicles; 29. In-vitro growth of human oocytes; 30. Contributions of ovarian stromal cells to follicle culture; 31. In-vitro maturation of germinal vesicle oocytes; 32. Survival of primordial follicles: tips and tricks; Section 9 New research and technologies: 33. The artificial ovary; 34. Uterus transplantation: research and clinical possibilities; 35. Ovarian allotransplantation; 36. Allotransplantation of human ovarian tissue; 37. Predicting ovarian futures: the contribution of genetics; Section 10 Ethical, legal and religious issues: 38. Fertility preservation: ethical considerations; 39. Legal issues of fertility preservation; 40. Christian ethics in fertility preservation.