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Fundamentals of Modern Bioprocessing

Autor Sarfaraz K. Niazi, Justin L. Brown
en Limba Engleză Paperback – 26 iul 2017
Biological drug and vaccine manufacturing has quickly become one of the highest-value fields of bioprocess engineering, and many bioprocess engineers are now finding job opportunities that have traditionally gone to chemical engineers. Fundamentals of Modern Bioprocessing addresses this growing demand.
Written by experts well-established in the field, this book connects the principles and applications of bioprocessing engineering to healthcare product manufacturing and expands on areas of opportunity for qualified bioprocess engineers and students. The book is divided into two sections: the first half centers on the engineering fundamentals of bioprocessing; while the second half serves as a handbook offering advice and practical applications.
Focused on the fundamental principles at the core of this discipline, this work outlines every facet of design, component selection, and regulatory concerns. It discusses the purpose of bioprocessing (to produce products suitable for human use), describes the manufacturing technologies related to bioprocessing, and explores the rapid expansion of bioprocess engineering applications relevant to health care product manufacturing. It also considers the future of bioprocessing—the use of disposable components (which is the fastest growing area in the field of bioprocessing) to replace traditional stainless steel.
In addition, this text:
  • Discusses the many types of genetically modified organisms
  • Outlines laboratory techniques
  • Includes the most recent developments
  • Serves as a reference and contains an extensive bibliography
  • Emphasizes biological manufacturing using recombinant processing, which begins with creating a genetically modified organism using recombinant techniques
Fundamentals of Modern Bioprocessing outlines both the principles and applications of bioprocessing engineering related to healthcare product manufacturing. It lays out the basic concepts, definitions, methods and applications of bioprocessing. A single volume comprehensive reference developed to meet the needs of students with a bioprocessing background; it can also be used as a source for professionals in the field.
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Specificații

ISBN-13: 9781138893290
ISBN-10: 1138893293
Pagini: 768
Ilustrații: 91 Tables, black and white; 14 Illustrations, color; 95 Illustrations, black and white
Dimensiuni: 178 x 254 x 47 mm
Greutate: 1.4 kg
Ediția:1
Editura: CRC Press
Colecția CRC Press

Cuprins

Engineering Fundamentals of Bioprocessing. Frontiers of Bioprocessing. Introduction to Molecular Biology. Introduction to Biochemistry. Introduction to Cellular Microbiology. Reaction Stoichiometry, Thermodynamics, and Kinetics. Kinetics of Enzymes and Cell Growth. Data Management. Handbook of Bioprocessing. Elements of Bioprocessing. Genetically Modified Organisms. Manufacturing Overview. Disposable Bioprocessing Systems. Upstream Processing. Downstream Processing. Purification. Manufacturing Systems. Quality Consideration. Intellectual Property. Bibliography.

Notă biografică

Sarfaraz K. Niazi, Ph.D., is the founding executive chairman of Therapeutic Proteins International, LLC. He began his career teaching pharmacy at the University of Illinois, where he was a tenured professor, before entering the pharmaceutical industry with Abbott International, where he became a Volwiler fellow. Dr. Niazi is a licensed practitioner of patent law, has published numerous books and papers, and has been recognized with several awards for his contributions to science and literature. His inventions, philanthropy, and passion for science, literature, music, and photography have also been documented in publications such as Forbes, Chicago Tribune, and Crain’s Chicago Business.
Justin L. Brown, Ph.D., joined the biomedical engineering faculty of The Pennsylvania State University in 2010. Prior to joining Penn State, Dr. Brown spent seven years at the University of Virginia where he obtained his Ph.D. in biomedical engineering and completed a postdoctoral fellowship in cell and microbiology. His current research interests focus on exploring the signaling cascades and lineage commitment of mesenchymal stem cells in response to biomaterial surfaces that have potential for translation to clinical strategies. Dr. Brown’s lab applies both a reductionist and high-throughput systems approach towards understanding the mechanistic cellular response to extracellular biomaterial geometries.

Recenzii

"… destined to become a standard handbook for bioprocess engineers. It provides a detailed discussion of emerging areas, such as disposable bioreactors, that are scarcely covered in the books that are currently available."
—Jules Magda, University of Utah, Salt Lake City, USA

Descriere

This comprehensive bioprocessing textbook deals with the basic concepts, definitions, methods, and applications of the use of biological catalysts to deliver products of high value and utility, from alcohol to recombinant monoclonal antibodies to common day use fuel. It covers all modern aspects, including the means of processing that are required for drug processing to the use of biofuels, downstream bioprocessing, bioprocess design, and regulatory affairs, among many other cutting-edge topics. Applications and case studies are incorporated throughout.